Literature DB >> 8758019

Insulin resistance and development of diabetes mellitus associated with megestrol acetate therapy.

P Jain1, L S Girardi, L Sherman, M Berelowicz, L G Smith.   

Abstract

We describe a case of diabetes mellitus induced by megestrol acetate in a patient with the acquired immunodeficiency syndrome. Metabolic studies including an arginine infusion test excluded an insulinopenic state and suggested insulin resistance as the underlying mechanism for hyperglycaemia. Withdrawal of megestrol acetate resulted in rapid correction of all metabolic abnormalities and eliminated the need for exogenous insulin therapy.

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Year:  1996        PMID： 8758019      PMCID： PMC2398479          DOI： 10.1136/pgmj.72.848.365

Source DB:  PubMed          Journal:  Postgrad Med J        ISSN： 0032-5473            Impact factor:   2.401


  10 in total

1.  Hyperglycemia induced by megestrol acetate.

Authors:  A P Panwalker
Journal:  Ann Intern Med       Date:  1992-05-15       Impact factor: 25.391

2.  Diabetes mellitus induced by megestrol acetate in a patient with AIDS and cachexia.

Authors:  K Henry; S Rathgaber; C Sullivan; K McCabe
Journal:  Ann Intern Med       Date:  1992-01-01       Impact factor: 25.391

3.  The effect of continuous subdermal levonorgestrel (Norplant) on carbohydrate metabolism.

Authors:  J C Konje; E O Otolorin; O A Ladipo
Journal:  Am J Obstet Gynecol       Date:  1992-01       Impact factor: 8.661

4.  HIV and the pancreas.

Authors: 
Journal:  Lancet       Date:  1987-11-21       Impact factor: 79.321

5.  Effects of pregnancy and sex steroid administration on skeletal muscle metabolism in the rat.

Authors:  R J Rushakoff; R K Kalkhoff
Journal:  Diabetes       Date:  1981-07       Impact factor: 9.461

6.  Usefulness of megestrol acetate in cancer cachexia and anorexia. A placebo-controlled study.

Authors:  J Feliu; M González-Barón; A Berrocal; A Artal; A Ordóñez; P Garrido; P Zamora; M L García de Paredes; J M Montero
Journal:  Am J Clin Oncol       Date:  1992-10       Impact factor: 2.339

7.  Body-composition changes in patients who gain weight while receiving megestrol acetate.

Authors:  C L Loprinzi; D J Schaid; A M Dose; N L Burnham; M D Jensen
Journal:  J Clin Oncol       Date:  1993-01       Impact factor: 44.544

8.  Progesterone and insulin-resistance: studies of progesterone action on glucose transport, lipogenesis and lipolysis in isolated fat cells of the female rat.

Authors:  M T Sutter-Dub; B Dazey; E Hamdan; M T Vergnaud
Journal:  J Endocrinol       Date:  1981-03       Impact factor: 4.286

9.  Megestrol acetate-induced differentiation of 3T3-L1 adipocytes in vitro.

Authors:  A W Hamburger; H Parnes; G B Gordon; L M Shantz; K A O'Donnell; J Aisner
Journal:  Semin Oncol       Date:  1988-04       Impact factor: 4.929

10.  Diabetes mellitus following pentamidine-induced hypoglycemia in humans.

Authors:  P Bouchard; P Sai; G Reach; I Caubarrère; D Ganeval; R Assan
Journal:  Diabetes       Date:  1982-01       Impact factor: 9.461
  10 in total
  1 in total

Review 1.  Drug-Induced Hyperglycaemia and Diabetes.

Authors:  Neila Fathallah; Raoudha Slim; Sofien Larif; Houssem Hmouda; Chaker Ben Salem
Journal:  Drug Saf       Date:  2015-12       Impact factor: 5.606
  1 in total

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