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Literature DB >> 8755567

1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.

Entities: Chemical Disease Gene Species

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Year: 1996 PMID： 8755567 PMCID： PMC38839 DOI： 10.1073/pnas.93.15.7861

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

18 in total

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Authors: S M Smith; N S Levy; C E Hayes
Journal: J Nutr Date: 1987-05 Impact factor: 4.798

2. 1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells.

Authors: J M Lemire; J S Adams; R Sakai; S C Jordan
Journal: J Clin Invest Date: 1984-08 Impact factor: 14.808

3. 1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis.

Authors: J M Lemire; D C Archer
Journal: J Clin Invest Date: 1991-03 Impact factor: 14.808

4. Prevention of murine experimental allergic encephalomyelitis: cooperative effects of cyclosporine and 1 alpha, 25-(OH)2D3.

Authors: D D Branisteanu; M Waer; H Sobis; S Marcelis; M Vandeputte; R Bouillon
Journal: J Neuroimmunol Date: 1995-09 Impact factor: 3.478

5. Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA.

Authors: W F Rigby; S Denome; M W Fanger
Journal: J Clin Invest Date: 1987-06 Impact factor: 14.808

6. Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues.

Authors: H P Koeffler; T Amatruda; N Ikekawa; Y Kobayashi; H F DeLuca
Journal: Cancer Res Date: 1984-12 Impact factor: 12.701

7. Induction of common mucosal immunity by hormonally immunomodulated peripheral immunization.

Authors: R A Daynes; E Y Enioutina; S Butler; H H Mu; Z A McGee; A Araneo B
Journal: Infect Immun Date: 1996-04 Impact factor: 3.441

8. 1,25-dihydroxyvitamin D3 receptors in human leukocytes.

Authors: D M Provvedini; C D Tsoukas; L J Deftos; S C Manolagas
Journal: Science Date: 1983-09-16 Impact factor: 47.728

9. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation.

Authors: A K Bhalla; E P Amento; T L Clemens; M F Holick; S M Krane
Journal: J Clin Endocrinol Metab Date: 1983-12 Impact factor: 5.958

10. Inhibition of interleukin-1 production by 1,25-dihydroxyvitamin D3.

Authors: C D Tsoukas; D Watry; S S Escobar; D M Provvedini; C A Dinarello; F G Hustmyer; S C Manolagas
Journal: J Clin Endocrinol Metab Date: 1989-07 Impact factor: 5.958

181 in total

1. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.

Authors: L D Brewer; V Thibault; K C Chen; M C Langub; P W Landfield; N M Porter
Journal: J Neurosci Date: 2001-01-01 Impact factor: 6.167

1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.

1. Impaired immunity in vitamin A-deficient mice.

2. 1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells.

3. 1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis.

4. Prevention of murine experimental allergic encephalomyelitis: cooperative effects of cyclosporine and 1 alpha, 25-(OH)2D3.

5. Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA.

6. Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues.

7. Induction of common mucosal immunity by hormonally immunomodulated peripheral immunization.

8. 1,25-dihydroxyvitamin D3 receptors in human leukocytes.

9. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation.

10. Inhibition of interleukin-1 production by 1,25-dihydroxyvitamin D3.

1. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons.

Review 2. Complementary and alternative medicine: is there a role in multiple sclerosis?

3. UV radiation suppresses experimental autoimmune encephalomyelitis independent of vitamin D production.

Review 4. Does vitamin D affect risk of developing autoimmune disease?: a systematic review.

5. Association between vitamin D status and age-related macular degeneration by genetic risk.

6. 1,25-Dihydroxyvitamin D3 selectively and reversibly impairs T helper-cell CNS localization.

7. Preclinical serum 25-hydroxyvitamin D levels and risk of type 1 diabetes in a cohort of US military personnel.

8. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.

Review 9. The neuropathology of obesity: insights from human disease.

10. The link between vitamin D deficiency and systemic lupus erythematosus.