Literature DB >> 8752213

Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

S Piccolo1, Y Sasai, B Lu, E M De Robertis.   

Abstract

Chordin (Chd) is an abundant protein secreted by Spemann organizer tissue during gastrulation. Chd antagonizes signaling by mature bone morphogenetic proteins (BMPs) by blocking binding to their receptors. Recombinant Xenopus Chd binds to BMP-4 with high affinity (KD, 3 x 10(-10) M), binding specifically to BMPs but not to activin or TGF-beta1. Chd protein is able to dorsalize mesoderm and to neuralize ectoderm in Xenopus gastrula explants at 1 nM. We propose that the noncell-autonomous effects of Spemann's organizer on dorsoventral patterning are executed in part by diffusible signals that directly bind to and neutralize ventral BMPs during gastrulation.

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Year:  1996        PMID： 8752213      PMCID： PMC3070603          DOI： 10.1016/s0092-8674(00)80132-4

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  46 in total

1.  Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo.

Authors:  J M Graff; R S Thies; J J Song; A J Celeste; D A Melton
Journal:  Cell       Date:  1994-10-07       Impact factor: 41.582

2.  Xenopus chordin and Drosophila short gastrulation genes encode homologous proteins functioning in dorsal-ventral axis formation.

Authors:  V François; E Bier
Journal:  Cell       Date:  1995-01-13       Impact factor: 41.582

3.  Developmental biology. Dismantling the organizer.

Authors:  E M De Robertis
Journal:  Nature       Date:  1995-03-30       Impact factor: 49.962

4.  Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes.

Authors:  Y Sasai; B Lu; H Steinbeisser; D Geissert; L K Gont; E M De Robertis
Journal:  Cell       Date:  1994-12-02       Impact factor: 41.582

5.  Neural induction by the secreted polypeptide noggin.

Authors:  T M Lamb; A K Knecht; W C Smith; S E Stachel; A N Economides; N Stahl; G D Yancopolous; R M Harland
Journal:  Science       Date:  1993-10-29       Impact factor: 47.728

6.  Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus.

Authors:  M Taira; H Otani; J P Saint-Jeannet; I B Dawid
Journal:  Nature       Date:  1994-12-15       Impact factor: 49.962

7.  A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

Authors:  A Suzuki; R S Thies; N Yamaji; J J Song; J M Wozney; K Murakami; N Ueno
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

8.  Efficient expression of a heterodimer of bone morphogenetic protein subunits using a baculovirus expression system.

Authors:  M Hazama; A Aono; N Ueno; Y Fujisawa
Journal:  Biochem Biophys Res Commun       Date:  1995-04-26       Impact factor: 3.575

9.  Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene.

Authors:  V Francois; M Solloway; J W O'Neill; J Emery; E Bier
Journal:  Genes Dev       Date:  1994-11-01       Impact factor: 11.361

10.  On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.

Authors:  A Fainsod; H Steinbeisser; E M De Robertis
Journal:  EMBO J       Date:  1994-11-01       Impact factor: 11.598
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  192 in total

Review 1.  The establishment of Spemann's organizer and patterning of the vertebrate embryo.

Authors:  E M De Robertis; J Larraín; M Oelgeschläger; O Wessely
Journal:  Nat Rev Genet       Date:  2000-12       Impact factor: 53.242

Review 2.  The Spemann organizer and embryonic head induction.

Authors:  C Niehrs
Journal:  EMBO J       Date:  2001-02-15       Impact factor: 11.598

3.  Neural induction in the absence of mesoderm: beta-catenin-dependent expression of secreted BMP antagonists at the blastula stage in Xenopus.

Authors:  O Wessely; E Agius; M Oelgeschläger; E M Pera; E M De Robertis
Journal:  Dev Biol       Date:  2001-06-01       Impact factor: 3.582

4.  Sox17 and chordin are required for formation of Kupffer's vesicle and left-right asymmetry determination in zebrafish.

Authors:  Emil Aamar; Igor B Dawid
Journal:  Dev Dyn       Date:  2010-11       Impact factor: 3.780

5.  Studies on the role of fibroblast growth factor signaling in neurogenesis using conjugated/aged animal caps and dorsal ectoderm-grafted embryos.

Authors:  R H Xu; J Kim; M Taira; D Sredni; H Kung
Journal:  J Neurosci       Date:  1997-09-15       Impact factor: 6.167

Review 6.  Systems control of BMP morphogen flow in vertebrate embryos.

Authors:  Jean-Louis Plouhinec; Lise Zakin; Edward M De Robertis
Journal:  Curr Opin Genet Dev       Date:  2011-09-19       Impact factor: 5.578

7.  Clonal neural stem cells from human embryonic stem cell colonies.

Authors:  Radha Chaddah; Margot Arntfield; Susan Runciman; Laura Clarke; Derek van der Kooy
Journal:  J Neurosci       Date:  2012-06-06       Impact factor: 6.167

Review 8.  Specificity in transforming growth factor-beta signaling pathways.

Authors:  C J Ring; K W Cho
Journal:  Am J Hum Genet       Date:  1999-03       Impact factor: 11.025

9.  Chordin forms a self-organizing morphogen gradient in the extracellular space between ectoderm and mesoderm in the Xenopus embryo.

Authors:  Jean-Louis Plouhinec; Lise Zakin; Yuki Moriyama; Edward M De Robertis
Journal:  Proc Natl Acad Sci U S A       Date:  2013-11-27       Impact factor: 11.205

10.  The maternal CCAAT box transcription factor which controls GATA-2 expression is novel and developmentally regulated and contains a double-stranded-RNA-binding subunit.

Authors:  R L Orford; C Robinson; J M Haydon; R K Patient; M J Guille
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272
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