[A case of AFP (alpha-fetoprotein) producing gastric cancer successfully treated with FEP (5-FU, Epirubicin, cisplatin) therapy by continuous venous daily infusion of 5-FU and low-dose CDDP].

We reported our experience with a case of AFP producing gastric cancer with liver metastasis successfully treated with FEP therapy by continuous daily venous infusion of 5-FU and low-dose CDDP. A 59-year-old male was diagnosed with liver metastasis 2 months after partial gastrectomy of gastric cancer and then admitted. The patient received five courses of 24-hour continuous infusion of CDDP (5 mg/day, on day 1, 2, 3, 4, 5) and 5-FU (250 mg/day, on day 1, 3, 5) and bolus infusion of Epirubicin (10 mg/day, on day 3). No remarkable side effect was encountered. Complete response at the liver metastasis was observed by CT scan. Serum AFP level was down from 614 ng/ml to the normal range of 0.5 ng/ml after the therapy. The patient has been well for 10 months with complete remission.