Levels of superoxide dismutase mRNA in rat lens: effect of aging.

Superoxide dismutase, the enzyme catalyzing the dismutation of O2.- to H2O2 is known to be present in various ocular and nonocular tissues. In this communication we have determined the gene expression of this enzyme in rat lenses. The investigations have been conducted as a function of age using RNase protection assay. These in vitro assays for the corresponding mRNA suggested that the transcription of the gene is age variant, increasing as a function of age. The levels were significantly lower in the young lenses in comparison to the older lenses.