Literature DB >> 8750928

Defective calcium transport in vitiliginous melanocytes.

K U Schallreuter-Wood1, M R Pittelkow, N N Swanson.   

Abstract

Melanocytes were successfully established from involved and uninvolved skin of a patient with acute acrofacial vitiligo. Cells from involved epidermis showed a fivefold decrease in the rate of radiolabelled 45Ca uptake compared with uninvolved and control cells. These results are similar to previous findings in keratinocytes from involved skin in patients with vitiligo. Since 6-biopterin is cytotoxic to melanocytes and calcium controls the redox status of the 6-biopterin/(6R)5, 6, 7, 8-tetrahydrobiopterin equilibrium via the thioredoxin reductase/thioredoxin system, these results underline the importance of this electron transfer system for both melanocyte function and survival.

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Year:  1996        PMID： 8750928     DOI： 10.1007/bf02505036

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  20 in total

1.  A new spectrophotometric assay for protein in cell extracts.

Authors:  V F Kalb; R W Bernlohr
Journal:  Anal Biochem       Date:  1977-10       Impact factor: 3.365

2.  Defective calcium uptake in keratinocyte cell cultures from vitiliginous skin.

Authors:  K U Schallreuter; M P Pittelkow
Journal:  Arch Dermatol Res       Date:  1988       Impact factor: 3.017

3.  Beta-adrenergic stimulation induces intracellular Ca++ increase in human epidermal keratinocytes.

Authors:  H Koizumi; C Yasui; T Fukaya; A Ohkawara; T Ueda
Journal:  J Invest Dermatol       Date:  1991-02       Impact factor: 8.551

4.  Increased monoamine oxidase A activity in the epidermis of patients with vitiligo.

Authors:  K U Schallreuter; J M Wood; M R Pittelkow; G Buttner; N Swanson; C Korner; C Ehrke
Journal:  Arch Dermatol Res       Date:  1996       Impact factor: 3.017

5.  Defective tetrahydrobiopterin and catecholamine biosynthesis in the depigmentation disorder vitiligo.

Authors:  K U Schallreuter; J M Wood; I Ziegler; K R Lemke; M R Pittelkow; N J Lindsey; M Gütlich
Journal:  Biochim Biophys Acta       Date:  1994-05-25

6.  Increased in vitro expression of beta 2-adrenoceptors in differentiating lesional keratinocytes of vitiligo patients.

Authors:  K U Schallreuter; J M Wood; M R Pittelkow; N N Swanson; V Steinkraus
Journal:  Arch Dermatol Res       Date:  1993       Impact factor: 3.017

7.  Cytotoxicity of 6-biopterin to human melanocytes.

Authors:  K U Schallreuter; G Büttner; M R Pittelkow; J M Wood; N N Swanson; C Körner
Journal:  Biochem Biophys Res Commun       Date:  1994-10-14       Impact factor: 3.575

8.  Investigation of the personality structure in patients with vitiligo and a possible association with impaired catecholamine metabolism.

Authors:  B A Salzer; K U Schallreuter
Journal:  Dermatology       Date:  1995       Impact factor: 5.366

9.  Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry.

Authors:  G K Menon; S Grayson; P M Elias
Journal:  J Invest Dermatol       Date:  1985-06       Impact factor: 8.551

10.  Free radical reduction by thioredoxin reductase at the surface of normal and vitiliginous human keratinocytes.

Authors:  K U Schallreuter; M R Pittelkow; J M Wood
Journal:  J Invest Dermatol       Date:  1986-12       Impact factor: 8.551
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  6 in total

1.  Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress.

Authors:  Jeffrey A Mosenson; Kelsey Flood; Jared Klarquist; Jonathan M Eby; Amy Koshoffer; Raymond E Boissy; Andreas Overbeck; Rebecca C Tung; I Caroline Le Poole
Journal:  Pigment Cell Melanoma Res       Date:  2014-01-13       Impact factor: 4.693

2.  'VIT1', a novel gene associated with vitiligo.

Authors:  I C Le Poole; R Sarangarajan; Y Zhao; L S Stennett; T L Brown; P Sheth; T Miki; R E Boissy
Journal:  Pigment Cell Res       Date:  2001-12

3.  Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.

Authors:  Stanca A Birlea; Katherine Gowan; Pamela R Fain; Richard A Spritz
Journal:  J Invest Dermatol       Date:  2009-11-05       Impact factor: 8.551

4.  Calcium homeostasis in human melanocytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light.

Authors:  Sulochana Devi; Rajendra Kedlaya; Nityanand Maddodi; Kumar M R Bhat; Craig S Weber; Hector Valdivia; Vijayasaradhi Setaluri
Journal:  Am J Physiol Cell Physiol       Date:  2009-07-08       Impact factor: 4.249

5.  Potential Role of Chronic Physical Exercise as a Treatment in the Development of Vitiligo.

Authors:  Elias de França; Ronaldo V T Dos Santos; Liliana C Baptista; Marco A R Da Silva; André R Fukushima; Vinícius B Hirota; Raul A Martins; Erico C Caperuto
Journal:  Front Physiol       Date:  2022-03-10       Impact factor: 4.566

6.  Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating Ca2+ influx via TRPM1 channels.

Authors:  Qiong Jia; Shixiong Hu; Dingxing Jiao; Xiuqing Li; Shuhui Qi; Ruiwen Fan
Journal:  Cell Biochem Funct       Date:  2019-11-19       Impact factor: 3.685
  6 in total

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