Literature DB >> 8750908

In vitro biotransformation of 2-methylpropene (isobutene) in rat lung tissue in comparison with liver tissue.

M Cornet1, A Callaerts, A Vercruysse, V Rogiers.   

Abstract

The epoxidation of the gaseous alkene 2-methylpropene or isobutene was studied in vitro in rat lung tissue in comparison with rat liver. Pulmonary tissue appears to be less exposed to the toxic epoxide metabolite than is the case for hepatic tissue. The results are correlated with the low capacity of the mixed function oxidase system, expressed by means of the cytochrome P-450 content and the 7-ethoxycoumarin O-deethylase activity, to form reactive intermediates. The activities of the principal epoxide detoxifying enzymes glutathione S-transferase and epoxide hydrolase represent only 5-10% of the values measured in rat liver.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8750908     DOI： 10.1007/s002040050251

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  24 in total

Review 1.  Xenobiotic metabolism by isolated pulmonary cells.

Authors:  T R Devereux; B A Domin; R M Philpot
Journal:  Pharmacol Ther       Date:  1989       Impact factor: 12.310

Review 2.  Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue.

Authors:  F P Guengerich
Journal:  Pharmacol Ther       Date:  1990       Impact factor: 12.310

3.  In situ localization and distribution of xenobiotic-activating enzymes and aryl hydrocarbon hydroxylase activity in lungs of untreated rats.

Authors:  J M Voigt; T T Kawabata; J P Burke; M V Martin; F P Guengerich; J Baron
Journal:  Mol Pharmacol       Date:  1990-02       Impact factor: 4.436

4.  Investigation of species differences in isobutene (2-methylpropene) metabolism between mice and rats.

Authors:  G A Csanády; D Freise; B Denk; J G Filser; M Cornet; V Rogiers; R J Laib
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

Review 5.  Enzymatic activation of chemicals to toxic metabolites.

Authors:  F P Guengerich; D C Liebler
Journal:  Crit Rev Toxicol       Date:  1985       Impact factor: 5.635

Review 6.  Sites for xenobiotic activation and detoxication within the respiratory tract: implications for chemically induced toxicity.

Authors:  J Baron; J P Burke; F P Guengerich; W B Jakoby; J M Voigt
Journal:  Toxicol Appl Pharmacol       Date:  1988-05       Impact factor: 4.219

Review 7.  Pulmonary metabolism of xenobiotics.

Authors:  G E Hook; J R Bend
Journal:  Life Sci       Date:  1976-02-01       Impact factor: 5.037

8.  Cytochrome P-450- and glutathione-associated enzyme activities in freshly isolated enriched lung cell fractions from beta-naphthoflavone-treated male F344 rats.

Authors:  S A Lacy; J B Mangum; J I Everitt
Journal:  Toxicology       Date:  1992       Impact factor: 4.221

9.  Mutagenicity of 2-methylpropene (isobutene) and its epoxide in a modified Salmonella assay for volatile compounds.

Authors:  M Cornet; P Castelain; A Vercruysse; R Laib; M Kirsch-Volders; V Rogiers
Journal:  Mutat Res       Date:  1992-06       Impact factor: 2.433

10.  The results of microbial mutation test for forty-three industrial chemicals.

Authors:  H Shimizu; Y Suzuki; N Takemura; S Goto; H Matsushita
Journal:  Sangyo Igaku       Date:  1985-11
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.