Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver.

Literature DB >> 8750907

Tissue specific basal expression of soluble murine epoxide hydrolase and effects of clofibrate on the mRNA levels in extrahepatic tissues and liver.

C Johansson¹, A Stark, M Sandberg, B Ek, L Rask, J Meijer.

Abstract

The soluble epoxide hydrolase mRNA level in liver was increased eight-fold upon administration of the hypolipidemic drug and peroxisome proliferator clofibrate for 7 days to mice. The soluble epoxide hydrolase mRNA was back at control levels within 1-2 days after clofibrate withdrawal. The highest expression was in liver, intestine and kidney. Lower levels were found in heart and muscle and very low levels were found in testes, lung, brain and spleen. The mRNA levels were increased in liver, kidney and heart by clofibrate.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1995 PMID： 8750907 DOI： 10.1007/s002040050250

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

14 in total

1. Expression of chicken beta-actin in Saccharomyces cerevisiae.

Authors: R Karlsson
Journal: Gene Date: 1988-09-07 Impact factor: 3.688

Review 2. Biogenesis of peroxisomes.

Authors: P B Lazarow; Y Fujiki
Journal: Annu Rev Cell Biol Date: 1985

Review 3. Genetic toxicity of some important epoxides.

Authors: L Ehrenberg; S Hussain
Journal: Mutat Res Date: 1981-01 Impact factor: 2.433

4. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene.

Authors: J Y Tso; X H Sun; T H Kao; K S Reece; R Wu
Journal: Nucleic Acids Res Date: 1985-04-11 Impact factor: 16.971

5. In vitro translation of cytosolic and peroxisomal epoxide hydrolase and catalase on liver polyribosomes from untreated and clofibrate-treated C57B1/6 mice.

Authors: V Joste; J Meijer
Journal: FEBS Lett Date: 1989-05-22 Impact factor: 4.124

6. Effects of clofibrate withdrawal on peroxisomes in mouse hepatocytes.

Authors: J Meijer; C Starkerud; B A Afzelius
Journal: Eur J Cell Biol Date: 1993-04 Impact factor: 4.492

Review 7. Cytosolic epoxide hydrolase.

Authors: J Meijer; J W DePierre
Journal: Chem Biol Interact Date: 1988 Impact factor: 5.192

8. Molecular cloning and expression of murine liver soluble epoxide hydrolase.

Authors: D F Grant; D H Storms; B D Hammock
Journal: J Biol Chem Date: 1993-08-15 Impact factor: 5.157

9. Properties of cytosolic epoxide hydrolase purified from the liver of untreated and clofibrate-treated mice. Purification procedure and physiochemical characterization of the pure enzymes.

Authors: J Meijer; J W Depierre
Journal: Eur J Biochem Date: 1985-05-02

10. An impaired peroxisomal targeting sequence leading to an unusual bicompartmental distribution of cytosolic epoxide hydrolase.

Authors: M Arand; M Knehr; H Thomas; H D Zeller; F Oesch
Journal: FEBS Lett Date: 1991-12-02 Impact factor: 4.124

7 in total

1. Epoxyeicosatrienoic acids and soluble epoxide hydrolase: potential therapeutic targets for inflammation and its induced carcinogenesis.

Authors: Stephanie Norwood; Jie Liao; Bruce D Hammock; Guang-Yu Yang
Journal: Am J Transl Res Date: 2010-07-22 Impact factor: 4.060

Review 2. Soluble epoxide hydrolase: gene structure, expression and deletion.

Authors: Todd R Harris; Bruce D Hammock
Journal: Gene Date: 2013-05-20 Impact factor: 3.688

Review 3. Epoxyeicosanoid signaling in CNS function and disease.

Authors: Jeffrey J Iliff; Jia Jia; Jonathan Nelson; Toru Goyagi; Judy Klaus; Nabil J Alkayed
Journal: Prostaglandins Other Lipid Mediat Date: 2009-06-21 Impact factor: 3.072

Review 4. Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis.

Authors: Ryan D Jones; Jie Liao; Xin Tong; Dandan Xu; Leyu Sun; Haonan Li; Guang-Yu Yang
Journal: Front Pharmacol Date: 2019-06-25 Impact factor: 5.810