M Küchle1, S A Vinores, J Mahlow, W R Green. 1. Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abstract
BACKGROUND: Alterations of the integrity of the blood-aqueous barrier (BAB) are frequent findings in eyes with pseudoexfoliation syndrome (PSX). METHODS: Immunohistochemical staining for the demonstration of albumin was used to analyze the BAB in 10 eyes with PSX without previous intraocular surgery and in 10 age-matched normal control eyes. RESULTS: In eyes with PSX, small amounts of albumin were detected along the anterior surface of the iris in 7, in the anterior chamber in 1, along the ciliary epithelium in 4, and in the trabecular meshwork in 9 of 10 eyes. PSX material was also immunoreactive. In the 10 normal control eyes, albumin was detected anterior to the iris stroma in 1 eye, in the anterior chamber in 2 eyes, in the trabecular meshwork in 1 eye, but not internal to the ciliary epithelium. CONCLUSIONS: Our findings indicate that impairment of the BAB in PSX can be localized at the level of the iris and, less frequently or to a lesser extent, at the level of the ciliary body.
BACKGROUND: Alterations of the integrity of the blood-aqueous barrier (BAB) are frequent findings in eyes with pseudoexfoliation syndrome (PSX). METHODS: Immunohistochemical staining for the demonstration of albumin was used to analyze the BAB in 10 eyes with PSX without previous intraocular surgery and in 10 age-matched normal control eyes. RESULTS: In eyes with PSX, small amounts of albumin were detected along the anterior surface of the iris in 7, in the anterior chamber in 1, along the ciliary epithelium in 4, and in the trabecular meshwork in 9 of 10 eyes. PSX material was also immunoreactive. In the 10 normal control eyes, albumin was detected anterior to the iris stroma in 1 eye, in the anterior chamber in 2 eyes, in the trabecular meshwork in 1 eye, but not internal to the ciliary epithelium. CONCLUSIONS: Our findings indicate that impairment of the BAB in PSX can be localized at the level of the iris and, less frequently or to a lesser extent, at the level of the ciliary body.
Authors: Guorong Li; Heather Schmitt; William M Johnson; Chanyoung Lee; Iris Navarro; Jenny Cui; Todd Fleming; María Gomez-Caraballo; Michael H Elliott; Joseph M Sherwood; Michael A Hauser; Sina Farsiu; C Ross Ethier; W Daniel Stamer Journal: FASEB J Date: 2020-07-05 Impact factor: 5.191
Authors: Janey L Wiggs; Basil Pawlyk; Edward Connolly; Michael Adamian; Joan W Miller; Louis R Pasquale; Ramez I Haddadin; Cynthia L Grosskreutz; Douglas J Rhee; Tiansen Li Journal: Invest Ophthalmol Vis Sci Date: 2014-02-10 Impact factor: 4.799