Literature DB >> 875053

Lower limb paralysis induced in mice by a temperature-sensitive mutant of Moloney leukemia virus.

J A McCarter, J K Ball, J V Frei.   

Abstract

A temperature-sensitive mutant of Moloney murine leukemia virus defective in an early function and injected into newborn mice produced lower limb paralysis. Susceptible mice were inbred strains CFW/D, CBA/H, C3H/Bi/Ka, and outbred NIH Swiss stock. Inbred W/Fu rats and C57BL/Ka mice did not develop the paralysis, though the latter were infected with virus; the sera from these mice produced paralysis in susceptible CFW mice.

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Year:  1977        PMID： 875053     DOI： 10.1093/jnci/59.1.179

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  20 in total

1.  Site-directed mutagenesis of the codon for Ile-25 in gPr80env alters the neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.

Authors:  P F Szurek; E Floyd; P H Yuen; P K Wong
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

2.  The reduced virulence of the thymotropic Moloney murine leukemia virus derivative MoMuLV-TB is mapped to 11 mutations within the U3 region of the long terminal repeat.

Authors:  P H Yuen; P F Szurek
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

3.  Oligodendrocytes are a major target of the toxicity of spongiogenic murine retroviruses.

Authors:  Amanda C Clase; Derek E Dimcheff; Cynthia Favara; David Dorward; Frank J McAtee; Lindsay E Parrie; David Ron; John L Portis
Journal:  Am J Pathol       Date:  2006-09       Impact factor: 4.307

4.  Noninflammatory spongiform polioencephalomyelopathy caused by a neurotropic temperature-sensitive mutant of Moloney murine leukemia virus TB.

Authors:  J F Zachary; C J Knupp; P K Wong
Journal:  Am J Pathol       Date:  1986-09       Impact factor: 4.307

5.  A 1.6-kilobase-pair fragment in the genome of the ts1 mutant of Moloney murine leukemia virus TB that is associated with temperature sensitivity, nonprocessing of Pr80env, and paralytogenesis.

Authors:  P H Yuen; D Malehorn; C Knupp; P K Wong
Journal:  J Virol       Date:  1985-05       Impact factor: 5.103

6.  Disparate regions of envelope protein regulate syncytium formation versus spongiform encephalopathy in neurological disease induced by murine leukemia virus TR.

Authors:  Samuel L Murphy; Marek J Honczarenko; Natalie V Dugger; Paul M Hoffman; Glen N Gaulton
Journal:  J Virol       Date:  2004-08       Impact factor: 5.103

7.  Isolation of paralysis-inducing murine leukemia viruses from Friend virus passaged in rats.

Authors:  K Kai; T Furuta
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

8.  Retrovirus antigens in brains of mice with scrapie- and murine leukemia virus-induced spongiform encephalopathy.

Authors:  P M Hoffman; O M Pitts; R G Rohwer; D C Gajdusek; S K Ruscetti
Journal:  Infect Immun       Date:  1982-10       Impact factor: 3.441

9.  A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.

Authors:  P F Szurek; P H Yuen; J K Ball; P K Wong
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

10.  Characterization of a progressive neurodegenerative disease induced by a temperature-sensitive Moloney murine leukemia virus infection.

Authors:  J A Bilello; O M Pitts; P M Hoffman
Journal:  J Virol       Date:  1986-08       Impact factor: 5.103
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