| Literature DB >> 874968 |
A W Douglas, M H Fisher, J J Fishinger, P Gund, E E Harris, G Olson, A A Patchett, W V Ruyle.
Abstract
4-Chlorobenzaldehyde 1-(4-chlorophenyl)-4(1H)-pyridinylidene hydrazone fluorusulfonate (4) was found to have excellent anticoccidial activity in chickens. The synthesis and biological evaluation of related analogues are presented. Presumably 4 shares a common mechanism of action with robenidine (25) since it was not active on a robenidine tolerant strain of E. tenella. Structural comparisons of the two molecules are presented.Entities:
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Year: 1977 PMID： 874968 DOI： 10.1021/jm00217a015
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446