Literature DB >> 8749064

Poly(ADP-ribosyl)ation as a fail-safe, transcription-independent, suicide mechanism in acutely DNA-damaged cells: a hypothesis.

A Nagele1.   

Abstract

Poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30) is an abundant nuclear protein that is highly conserved and constitutively expressed in all higher eukaryotic cells investigated. Today, after about two decades of intensive research, we have a fairly comprehensive picture of its remarkable enzymatic functions and of its molecular structure. Its physiological role, however, remains controversial. The present hypothesis attempts to reconcile the different findings. By extending an earlier hypothesis, it is proposed that poly(ADP-ribosyl)ation is primarily a mechanism to prevent survival of mutated, possibly apoptosis-incompetent, cells after acute DNA-damage. Recent reviews on PARP may be found in [1-4].

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Year:  1995        PMID： 8749064     DOI： 10.1007/bf01209751

Source DB:  PubMed          Journal:  Radiat Environ Biophys        ISSN： 0301-634X            Impact factor:   1.925


  36 in total

1.  The involvement of poly(ADP-ribose) polymerase in the degradation of NAD caused by gamma-radiation and N-methyl-N-nitrosourea.

Authors:  C J Skidmore; M I Davies; P M Goodwin; H Halldorsson; P J Lewis; S Shall; A A Zia'ee
Journal:  Eur J Biochem       Date:  1979-11-01

2.  Cancer. p53, guardian of the genome.

Authors:  D P Lane
Journal:  Nature       Date:  1992-07-02       Impact factor: 49.962

3.  Accumulation of 10-kilobase DNA replication intermediates in cells treated with 3-aminobenzamide.

Authors:  U Lönn; S Lönn
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

4.  DNA strand breaks, NAD metabolism, and programmed cell death.

Authors:  D A Carson; S Seto; D B Wasson; C J Carrera
Journal:  Exp Cell Res       Date:  1986-06       Impact factor: 3.905

5.  Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis.

Authors:  C Nosseri; S Coppola; L Ghibelli
Journal:  Exp Cell Res       Date:  1994-06       Impact factor: 3.905

6.  Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

Authors:  Z Q Wang; B Auer; L Stingl; H Berghammer; D Haidacher; M Schweiger; E F Wagner
Journal:  Genes Dev       Date:  1995-03-01       Impact factor: 11.361

Review 7.  Poly(ADP-ribose) polymerase: a molecular nick-sensor.

Authors:  G de Murcia; J Ménissier de Murcia
Journal:  Trends Biochem Sci       Date:  1994-04       Impact factor: 13.807

8.  Poly(ADP-ribose) Polymerase inhibitors preserve nicotinamide adenine dinucleotide and adenosine 5'-triphosphate pools in DNA-damaged cells: mechanism of stimulation of unscheduled DNA synthesis.

Authors:  J L Sims; S J Berger; N A Berger
Journal:  Biochemistry       Date:  1983-10-25       Impact factor: 3.162

9.  p53 mutations increase resistance to ionizing radiation.

Authors:  J M Lee; A Bernstein
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

10.  Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage.

Authors:  M S Satoh; G G Poirier; T Lindahl
Journal:  Biochemistry       Date:  1994-06-14       Impact factor: 3.162
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  2 in total

Review 1.  Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury.

Authors:  Robert Piotr Strosznajder; Henryk Jesko; Agata Zambrzycka
Journal:  Mol Neurobiol       Date:  2005       Impact factor: 5.590

2.  New mechanisms for transcriptional repression of ENaC And iNOS.

Authors:  Bruce C Kone; Zhang Wenzhang; Yu Zhiyuan
Journal:  Trans Am Clin Climatol Assoc       Date:  2007
  2 in total

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