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Literature DB >> 8748676

Effects of tacrine upon murine neuroblastoma cells.

P Zatta¹, P Zambenedetti, M B Marturano, M Palumbo, M Nicolini.

Abstract

Tacrine [9-amino-1,2,3,4-tetrahydroacridine] (THA), a potent acetylcholinesterasic inhibitor, is utilized in the pharmacological treatment of Alzheimer's disease (Birne and Arie, 1994). Cytopharmacology of THA is still largely to be discovered. In the present paper we report some effects produced by THA on murine neuroblastoma cells (N2A) used as an experimental model. N2A cells treated with THA at low concentration (1 mu M) showed a reduced cell's mitosis and a remarkable reduction of protein synthesis. Eventually, a marked reduction on the phosphorylation of proteins associated to neurofilaments 200 kD, is observed using specific antibody.

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Year: 1995 PMID： 8748676 DOI： 10.1007/bf01276507

Source DB: PubMed Journal: J Neural Transm Gen Sect

21 in total

Review 1. Putative mechanisms of action of tacrine in Alzheimer's disease.

Authors: A Adem
Journal: Acta Neurol Scand Suppl Date: 1992

2. Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.

Authors: J D McGhee; P H von Hippel
Journal: J Mol Biol Date: 1974-06-25 Impact factor: 5.469

3. Differential scanning calorimetry of nuclei reveals the loss of major structural features in chromatin by brief nuclease treatment.

Authors: N A Touchette; R D Cole
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

Effects of tacrine upon murine neuroblastoma cells.

Review 1. Putative mechanisms of action of tacrine in Alzheimer's disease.

2. Theoretical aspects of DNA-protein interactions: co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice.

3. Differential scanning calorimetry of nuclei reveals the loss of major structural features in chromatin by brief nuclease treatment.

4. A higher order chromatin structure that is lost during differentiation of mouse neuroblastoma cells.

5. Tetrahydroaminoacridine and Alzheimer's disease.

6. Effect of tacrine in Alzheimer's disease: or non-effect?

7. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

8. Multiple phosphorylation sites in mammalian neurofilament polypeptides.

9. Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons.

10. Tetrahydroaminoacridine in HIV infections. The THA Study Group.

1. Identification of lectin binding sites in the rat brain.