Literature DB >> 8748157

A transgenic mouse line with alpha-1,3/4-fucosyl-transferase cDNA: production and characteristics.

H Obama1, T Kaname, A Sudou, T Yanagida, S Ikematsu, M Ozawa, H Yoshida, R Kannagi, K I Yamamura, T Muramatsu.   

Abstract

cDNA of human alpha-1,3/4-fucosyltransferase (Fuc-TIII) was placed under the control of the chicken beta-actin promoter and cytomegalovirus enhancer, then introduced into male pronuclei of fertilized mouse eggs. A transgenic mouse line thus obtained exhibited enhanced expression of Lex (4C9) antigen in endothelial cells located in the glomerulus, sinusoidal capillaries of the liver and capillaries of the heart. Furthermore, in the transgenic mice, sialyl dimeric Lex (FH6) and sialyl Lea (2D3) antigens were strongly expressed in the glomerular endothelial cells.

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Year:  1995        PMID： 8748157     DOI： 10.1007/bf00731241

Source DB:  PubMed          Journal:  Glycoconj J        ISSN： 0282-0080            Impact factor:   2.916


  25 in total

Review 1.  Selectins: interpreters of cell-specific carbohydrate information during inflammation.

Authors:  L A Lasky
Journal:  Science       Date:  1992-11-06       Impact factor: 47.728

2.  Immunohistochemical localization of the carbohydrate antigen 4C9 in the mouse embryo: a reliable marker of mouse primordial germ cells.

Authors:  K Yoshinaga; H Muramatsu; T Muramatsu
Journal:  Differentiation       Date:  1991-11       Impact factor: 3.880

3.  A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis.

Authors:  M Nguyen; N A Strubel; J Bischoff
Journal:  Nature       Date:  1993-09-16       Impact factor: 49.962

4.  Efficient selection for high-expression transfectants with a novel eukaryotic vector.

Authors:  H Niwa; K Yamamura; J Miyazaki
Journal:  Gene       Date:  1991-12-15       Impact factor: 3.688

5.  Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A.

Authors:  A Takada; K Ohmori; N Takahashi; K Tsuyuoka; A Yago; K Zenita; A Hasegawa; R Kannagi
Journal:  Biochem Biophys Res Commun       Date:  1991-09-16       Impact factor: 3.575

6.  ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.

Authors:  M L Phillips; E Nudelman; F C Gaeta; M Perez; A K Singhal; S Hakomori; J C Paulson
Journal:  Science       Date:  1990-11-23       Impact factor: 47.728

7.  Location and distribution of difucoganglioside (VI3NeuAcV3III3Fuc2nLc6) in normal and tumor tissues defined by its monoclonal antibody FH6.

Authors:  Y Fukushi; R Kannagi; S Hakomori; T Shepard; B G Kulander; J W Singer
Journal:  Cancer Res       Date:  1985-08       Impact factor: 12.701

8.  Introduction of human gamma 1 immunoglobulin genes into fertilized mouse eggs.

Authors:  K Yamamura; H Kikutani; N Takahashi; T Taga; S Akira; K Kawai; K Fukuchi; Y Kumahara; T Honjo; T Kishimoto
Journal:  J Biochem       Date:  1984-08       Impact factor: 3.387

9.  Oligosaccharides containing fucose linked alpha(1-3) and alpha(1-4) to N-acetylglucosamine cause decompaction of mouse morulae.

Authors:  J M Bird; S J Kimber
Journal:  Dev Biol       Date:  1984-08       Impact factor: 3.582

10.  Transgenic mouse lines with ectopic expression of alpha-1,3-galactosyltransferase: production and characteristics.

Authors:  S Ikematsu; T Kaname; M Ozawa; S Yonezawa; E Sato; F Uehara; H Obama; K Yamamura; T Muramatsu
Journal:  Glycobiology       Date:  1993-12       Impact factor: 4.313
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  1 in total

Review 1.  Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology.

Authors:  P G Falk; L V Hooper; T Midtvedt; J I Gordon
Journal:  Microbiol Mol Biol Rev       Date:  1998-12       Impact factor: 11.056
  1 in total

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