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Literature DB >> 8747937

The importance of fluence rate in photodynamic therapy: is there a parallel with ionizing radiation dose-rate effects?

Abstract

Several similarities can be found between dose-rate effects in radiotherapy and fluence-rate effects in photodynamic therapy (PDT). At low dose rates repair of sublethal damage can occur, whereas at high dose rates oxygen depletion can decrease the effects of both therapies. The available literature for fluence-rate effects in PDT is discussed here in relation to therapeutic implications.

Entities: Chemical

Mesh：

Year: 1995 PMID： 8747937 DOI： 10.1016/0167-8140(95)01626-r

Source DB: PubMed Journal: Radiother Oncol ISSN： 0167-8140 Impact factor: 6.280

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Cited

8 in total

1. Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate.

Authors: Theresa M Busch; Hsing-Wen Wang; E Paul Wileyto; Guoqiang Yu; Ralph M Bunte
Journal: Radiat Res Date: 2010-09 Impact factor: 2.841

2. Photodynamic inactivation of the Na,K-ATPase occurs via different pathways.

Authors: F Killig; G Stark; H J Apell
Journal: J Membr Biol Date: 2004-08-01 Impact factor: 1.843

3. Application of lower fluence rate for less microvasculature damage and greater cell-killing during photodynamic therapy.

Authors: Tao Xu; Yingxing Li; Xing Wu
Journal: Lasers Med Sci Date: 2004-10-26 Impact factor: 3.161

4. Application of lower fluence rate for less microvasculature damage and greater cell-killing during photodynamic therapy.

Authors: Tao Xu; Yingxing Li; Xing Wu
Journal: Lasers Med Sci Date: 2005 Impact factor: 3.161

The importance of fluence rate in photodynamic therapy: is there a parallel with ionizing radiation dose-rate effects?

1. Increasing damage to tumor blood vessels during motexafin lutetium-PDT through use of low fluence rate.

2. Photodynamic inactivation of the Na,K-ATPase occurs via different pathways.

3. Application of lower fluence rate for less microvasculature damage and greater cell-killing during photodynamic therapy.

4. Application of lower fluence rate for less microvasculature damage and greater cell-killing during photodynamic therapy.

5. Light delivery over extended time periods enhances the effectiveness of photodynamic therapy.

Review 6. Functional consequences of oxidative membrane damage.

7. The effects of ultra low fluence rate single and repetitive photodynamic therapy on glioma spheroids.

Review 8. Photodynamic inactivation of mammalian viruses and bacteriophages.