Literature DB >> 8746117

Immunoadhesins: principles and applications.

S M Chamow1, A Ashkenazi.   

Abstract

The prototypic immunoadhesin is an antibody-like molecule that fuses the Fc region of an immunoglobulin and the ligand-binding region of a receptor or adhesion molecule. In this article, we review some important structural and functional principles of immunoadhesins. In addition, we highlight some unique advantages of immunoadhesins as experimental tools in biology, as well as some of their exciting potential applications in medicine.

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Year:  1996        PMID： 8746117     DOI： 10.1016/0167-7799(96)80921-8

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  16 in total

1.  Neutralization of hepatitis A virus (HAV) by an immunoadhesin containing the cysteine-rich region of HAV cellular receptor-1.

Authors:  E Silberstein; G Dveksler; G G Kaplan
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

2.  Regulation of learning by EphA receptors: a protein targeting study.

Authors:  R Gerlai; N Shinsky; A Shih; P Williams; J Winer; M Armanini; B Cairns; J Winslow; W Gao; H S Phillips
Journal:  J Neurosci       Date:  1999-11-01       Impact factor: 6.167

Review 3.  Recombinant analogues of prolactin, growth hormone, and placental lactogen: correlations between physical structure, binding characteristics, and activity.

Authors:  A Gertler
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-01       Impact factor: 2.673

4.  The isolation of novel phage display-derived human recombinant antibodies against CCR5, the major co-receptor of HIV.

Authors:  Moria Shimoni; Alon Herschhorn; Yelena Britan-Rosich; Moshe Kotler; Itai Benhar; Amnon Hizi
Journal:  Viral Immunol       Date:  2013-08       Impact factor: 2.257

Review 5.  Monoclonal antibodies in cancer therapy.

Authors:  R Gruber; E Holz; G Riethmüller
Journal:  Springer Semin Immunopathol       Date:  1996

6.  A hingeless Fc fusion system for site-specific cleavage by IdeS.

Authors:  Shabazz Novarra; Luba Grinberg; Keith W Rickert; Arnita Barnes; Susan Wilson; Manuel Baca
Journal:  MAbs       Date:  2016-05-21       Impact factor: 5.857

7.  Functional blockade of tyrosine kinase A in the rat basal forebrain by a novel antagonistic anti-receptor monoclonal antibody.

Authors:  A Cattaneo; S Capsoni; E Margotti; M Righi; E Kontsekova; P Pavlik; P Filipcik; M Novak
Journal:  J Neurosci       Date:  1999-11-15       Impact factor: 6.167

8.  The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain.

Authors:  Gabriele Ugolini; Sara Marinelli; Sonia Covaceuszach; Antonino Cattaneo; Flaminia Pavone
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-14       Impact factor: 11.205

9.  Immunoadhesins containing pre-S domains of hepatitis B virus large envelope protein are secreted and inhibit virus infection.

Authors:  Ning Chai; Severin Gudima; Jinhong Chang; John Taylor
Journal:  J Virol       Date:  2007-02-28       Impact factor: 5.103

Review 10.  Signal initiation in biological systems: the properties and detection of transient extracellular protein interactions.

Authors:  Gavin J Wright
Journal:  Mol Biosyst       Date:  2009-12
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