Literature DB >> 8745428

Modulation of the phenotypic diversity of sickle cell anemia.

M H Steinberg1.   

Abstract

Sickle cell anemia is noted for being phenotypically heterogeneous. This suggests that there are genetic influences that moderate the effects of the sickle hemoglobin mutation. In this review I focus on genetically determined modulation of hemoglobin concentration and fetal hemoglobin levels. Each of these variables has important influences upon sickle hemoglobin polymerization and the resulting pathophysiology.

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Year:  1996        PMID： 8745428     DOI： 10.3109/03630269609027906

Source DB:  PubMed          Journal:  Hemoglobin        ISSN： 0363-0269            Impact factor:   0.849


  3 in total

1.  Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

Authors:  Renzo Galanello; Serena Sanna; Lucia Perseu; Maria Carla Sollaino; Stefania Satta; Maria Eliana Lai; Susanna Barella; Manuela Uda; Gianluca Usala; Goncalo R Abecasis; Antonio Cao
Journal:  Blood       Date:  2009-08-20       Impact factor: 22.113

2.  Sickle cell disease patients in eastern province of Saudi Arabia suffer less severe acute chest syndrome than patients with African haplotypes.

Authors:  M K Alabdulaali
Journal:  Ann Thorac Med       Date:  2007-10       Impact factor: 2.219

3.  Comment on "Molecular analysis and association with clinical and laboratory manifestations in children with sickle cell anemia".

Authors:  Marilda Souza Goncalves
Journal:  Rev Bras Hematol Hemoter       Date:  2014-07-22
  3 in total

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