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Literature DB >> 8743898

Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins.

M I Mackness¹, B Mackness, P N Durrington, P W Connelly, R A Hegele.

Abstract

Human serum paraoxonase is located on an HDL. It has the capacity to retard the accumulation of lipid peroxides in LDL under oxidizing conditions in vitro. Paraoxonase has a genetic polymorphism that results in a single amino acid substitution. Evidence indicates that both the serum concentration of paraoxonase and an individual's genotype are related to plasma lipid and lipoprotein concentrations, and possibly also to coronary heart disease, implicating paraoxonase in the development of atherosclerosis.

Entities: Chemical Disease Gene Species

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Year: 1996 PMID： 8743898 DOI： 10.1097/00041433-199604000-00004

Source DB: PubMed Journal: Curr Opin Lipidol ISSN： 0957-9672 Impact factor: 4.776

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Cited

81 in total

Review 9. LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and in the cells: role of prooxidants vs. antioxidants.

Authors: M Aviram; B Fuhrman
Journal: Mol Cell Biochem Date: 1998-11 Impact factor: 3.396

10. Serum paraoxonase 1 activity is decreased in thyroid dysfunction.

Authors: F Azizi; F Raiszadeh; M Solati; A Etemadi; M Rahmani; M Arabi
Journal: J Endocrinol Invest Date: 2003-08 Impact factor: 4.256

Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins.

1. The effect of grape seed extracts on serum paraoxonase activities in streptozotocin-induced diabetic rats.

2. Is there a relationship between serum ox-LDL, oxidative stress, and PON1 in knee osteoarthritis?

3. Paraoxonase and arylesterase activity in bladder cancer.

4. Serum arylesterase and paraoxonase activity in patients with chronic hepatitis.

Review 5. The paraoxonase gene family and atherosclerosis.

Review 6. Genetic lipoprotein disorders and coronary atherosclerosis.

7. Correlation of paraoxonase1 activities with birth weight.

8. Alterations in the high density lipoprotein phenotype and HDL-associated enzymes in subjects with metabolic syndrome.

Review 9. LDL oxidation by arterial wall macrophages depends on the oxidative status in the lipoprotein and in the cells: role of prooxidants vs. antioxidants.

10. Serum paraoxonase 1 activity is decreased in thyroid dysfunction.