| Literature DB >> 8743889 |
Abstract
Recent data argue strongly that a protein complex termed chromatin assembly factor-1 (CAF-I) plays a major role in de novo nucleosome assembly during DNA replication. Human CAF-I deposits newly synthesized, acetylated histones onto replicated DNA in vitro and localizes to sites of DNA replication in S-phase cells. Specific lysines of the histones used for nucleosome assembly are acetylated; in the past year the first gene encoding a histone acetyltransferase was cloned. However, mechanistic links between histone acetylation and nucleosome assembly have not been established in vivo or in vitro.Entities:
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Year: 1996 PMID： 8743889 DOI： 10.1016/s0955-0674(96)80012-3
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382