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Literature DB >> 874364

The lumi-aggregometer: a new instrument for simultaneous measurement of secretion and aggregation by platelets.

R D Feinman, J Lubowsky, I Charo, M P Zabinski.

Abstract

We have developed a new instrument that simultaneously monitors aggregation and secretion of ATP from the same sample of platelets. Aggregation is determined by the usual turbidimetric method; secretion of ATP is followed by measuring luminescence from the firefly luciferase system at right angles to the aggregometer light path. Data are recorded on a two-pen strip chart recorder and reveal the temporal relations between the two platelet responses.

Entities: Chemical

Mesh：

Substances：
Adenosine Triphosphate

Year: 1977 PMID： 874364

Source DB: PubMed Journal: J Lab Clin Med ISSN： 0022-2143

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Cited

22 in total

1. In vivo and in vitro HeNe laser effects on phagocyte functions.

Authors: G Ricevuti; A Mazzone; C Monaia; P Fratino; R Degiulio; R Dell'Acqua; G Leonardi; A Jucci; S Sacchi
Journal: Inflammation Date: 1989-10 Impact factor: 4.092

2. Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B.

Authors: Majed A Refaai; Jessie Carter; Kelly F Henrichs; Donna C Davidson; Stephen J Pollock; Ann E Casey; Sherry L Spinelli; Richard P Phipps; Charles W Francis; Neil Blumberg
Journal: Transfusion Date: 2012-05-25 Impact factor: 3.157

3. Effect of common agonists on cytoplasmic ionized calcium concentration in platelets. Measurement with 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin.

Authors: J A Ware; P C Johnson; M Smith; E W Salzman
Journal: J Clin Invest Date: 1986-03 Impact factor: 14.808

4. Interrelations of platelet aggregation and secretion.

Authors: I F Charo; R D Feinman; T C Detwiler
Journal: J Clin Invest Date: 1977-10 Impact factor: 14.808

5. Disaggregation and reaggregation of 'irreversibly' aggregated platelets: a method for more complete evaluation of anti-platelet drugs.

Authors: G H Rao; J G White
Journal: Agents Actions Date: 1985-07

6. Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man.

Authors: G A FitzGerald; A R Brash; J A Oates; A K Pedersen
Journal: J Clin Invest Date: 1983-10 Impact factor: 14.808

The lumi-aggregometer: a new instrument for simultaneous measurement of secretion and aggregation by platelets.

1. In vivo and in vitro HeNe laser effects on phagocyte functions.

2. Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B.

3. Effect of common agonists on cytoplasmic ionized calcium concentration in platelets. Measurement with 2-methyl-6-methoxy 8-nitroquinoline (quin2) and aequorin.

4. Interrelations of platelet aggregation and secretion.

5. Disaggregation and reaggregation of 'irreversibly' aggregated platelets: a method for more complete evaluation of anti-platelet drugs.

6. Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man.

7. Mechanisms of platelet aggregation by viridans group streptococci.

Review 8. Role of plasma, platelets, and endothelial cells in tumor metastasis.

9. Spontaneous platelet aggregation in a hereditary giant platelet syndrome (MPS).

10. The role of platelet aggregation and release in fragment D-induced pulmonary dysfunction.