Literature DB >> 8742805

Role for the mesocortical dopamine system in the motivating effects of cocaine.

G F Koob1, B Caine, A Markou, L Pulvirenti, F Weiss.   

Abstract

The search for a neurobiological substrate for the stimulant and reinforcing properties of cocaine has focused for some time on a particular part of the forebrain, the mesocorticolimbic dopamine (DA) system. This mesocorticolimbic DA system innervates the region of the nucleus accumbens (NACC) (ventral striatum) in the anterior part of the basal forebrain and appears to play a critical role in mediating the acute reinforcing effects of cocaine and amphetamine. This chapter reviews the role of mesocorticolimbic DA in the reinforcing properties of psychomotor stimulants as measured by intravenous (IV) drug self-administration in rats. In addition, the primary neuropharmacological mechanism for cocaine reinforcement provides a rich substrate for studying nondopaminergic modulation of the reinforcing actions of cocaine.

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Year:  1994        PMID： 8742805

Source DB:  PubMed          Journal:  NIDA Res Monogr        ISSN： 1046-9516


  23 in total

1.  The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access.

Authors:  Laura Orio; Sunmee Wee; Amy H Newman; Luigi Pulvirenti; George F Koob
Journal:  Addict Biol       Date:  2010-04-29       Impact factor: 4.280

Review 2.  Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.

Authors:  Rita Z Goldstein; Nora D Volkow
Journal:  Am J Psychiatry       Date:  2002-10       Impact factor: 18.112

3.  On the positive and negative affective responses to cocaine and their relation to drug self-administration in rats.

Authors:  Aaron Ettenberg; Vira Fomenko; Konstantin Kaganovsky; Kerisa Shelton; Jennifer M Wenzel
Journal:  Psychopharmacology (Berl)       Date:  2015-02-07       Impact factor: 4.530

4.  Prenatal exposure to cocaine alters the development of conditioned place-preference to cocaine in adult mice.

Authors:  C J Malanga; Martina Pejchal; Barry E Kosofsky
Journal:  Pharmacol Biochem Behav       Date:  2007-06-21       Impact factor: 3.533

5.  Cocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channels.

Authors:  Scott C Steffensen; Seth R Taylor; Malia L Horton; Elise N Barber; Laura T Lyle; Sarah H Stobbs; David W Allison
Journal:  Eur J Neurosci       Date:  2008-11       Impact factor: 3.386

6.  Loss of functional specificity in the dorsal striatum of chronic cocaine users.

Authors:  Colleen A Hanlon; Michael J Wesley; Linda J Porrino
Journal:  Drug Alcohol Depend       Date:  2009-03-04       Impact factor: 4.492

7.  Dose-dependent differences in short ultrasonic vocalizations emitted by rats during cocaine self-administration.

Authors:  David J Barker; David H Root; Sisi Ma; Shaili Jha; Laura Megehee; Anthony P Pawlak; Mark O West
Journal:  Psychopharmacology (Berl)       Date:  2010-06-23       Impact factor: 4.530

8.  Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats.

Authors:  Christopher M Lack; Sara R Jones; David C S Roberts
Journal:  Psychopharmacology (Berl)       Date:  2007-09-19       Impact factor: 4.530

Review 9.  Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects.

Authors:  Maarten van den Buuse
Journal:  Schizophr Bull       Date:  2009-11-09       Impact factor: 9.306

10.  Effect of sub-chronic hydrocortisone on responses to amphetamine in normal male volunteers.

Authors:  Andrea J Hearn; Peter Gallagher; Bruce M Owen; Margaret S Smith; Stuart Watson; Allan H Young
Journal:  Psychopharmacology (Berl)       Date:  2003-09-23       Impact factor: 4.530
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