Advances in computational image processing for microscopy.

The field of electron microscopy applied to structural biology has made significant progress in the last 5 years, with many labs attempting the solution of ever more challenging problems. This work has demanded significant new resources for the computational analysis of the data collected from the microscope. The purpose of this paper is to review briefly the state of the art in image processing of microscope data and to serve as an introduction to this special issue of the journal.