Literature DB >> 8742472

Differential modulation of brain immediate early genes by intraperitoneal LiCl.

R Lamprecht1, Y Dudai.   

Abstract

We have used in situ hybridization to investigate the modulation of expression of the immediate early genes (IEGs) c-fos, fos-B, zif/268 and CREM in rat brain following oral administration of saccharin, i.p. injection of LiCl, and conditioned taste aversion (CTA) training in which these stimuli are used as the conditioned stimulus (CS) and the unconditioned stimulus (UCS), respectively. Modulation of c-fos, zif/268 and CREM was detected in the NTS, PBN, hypothalamic PVN and central nucleus of the amygdala after the administration of the UCS but not the CS. Our data are consonant with the hypothesis that differential and combinatorial expression of IEGs plays a role in encoding the representation of LiCl-induced malaise in the brain.

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Year:  1995        PMID: 8742472

Source DB:  PubMed          Journal:  Neuroreport        ISSN: 0959-4965            Impact factor:   1.837


  25 in total

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5.  Area postrema lesions attenuate LiCl-induced c-Fos expression correlated with conditioned taste aversion learning.

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7.  Prevention of cannabinoid withdrawal syndrome by lithium: involvement of oxytocinergic neuronal activation.

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8.  A combined method of laser capture microdissection and X-Gal histology to analyze gene expression in c-Fos-specific neurons.

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10.  D-Cycloserine enhances conditioned taste aversion learning in rats.

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