Literature DB >> 8741751

D2-family receptor distribution in human postmortem tissue: an autoradiographic study.

R A Lahti1, R C Roberts, C A Tamminga.   

Abstract

The distribution throughout the normal human brain of the dopamine D2-family of receptors were investigated autoradiographically. Three ligands were used, [3H]-YM-09151-2 to define the D2, D3, D4 receptors; [3H]raclopride the D2 D3 receptors; and [3H](+)-7-OH-DPAT, in the presence of GTP, demonstrates D3 distribution. [3H]-YM-09151-2 and [3H]raclopride binding were highest in caudate (121 vs 130 fmol mg(-1)), putamen (96 vs 136 fmol mg(-1)), and nucleus accumbens (113 vs 120 fmol mg(-1)). [3H]-YM-09151-2 also displayed significant binding in several cortical areas (56-39 fmol mg(-1)) and hippocampus (27 fmol mg-1). [3H](+)-7-OH-DPAT was highest in the nucleus accumbens. Based upon the ligands properties it is inferred that D2 distribution is highest in putamen, caudate and nucleus accumbens; D3 in the nucleus accumbens; D4 receptor in cortical areas and hippocampus.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 8741751     DOI： 10.1097/00001756-199512150-00015

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  11 in total

1.  Autoradiographic localization of the putative D4 dopamine receptor in rat brain.

Authors:  M C Defagot; M C Antonelli
Journal:  Neurochem Res       Date:  1997-04       Impact factor: 3.996

2.  Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D₂ and D₃ Receptors.

Authors:  Maarten E A Reith; Aloke K Dutta; Dana E Selley; Juan Zhen; Tamara Antonio; Joanna C Jacob; David K Grandy
Journal:  Neurochem Res       Date:  2015-12-31       Impact factor: 3.996

3.  Dynamic changes in striatal dopamine D2 and D3 receptor protein and mRNA in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) denervation in baboons.

Authors:  R D Todd; J Carl; S Harmon; K L O'Malley; J S Perlmutter
Journal:  J Neurosci       Date:  1996-12-01       Impact factor: 6.167

4.  Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease.

Authors:  John D McCorvy; Val J Watts; David E Nichols
Journal:  Psychopharmacology (Berl)       Date:  2012-01-06       Impact factor: 4.530

5.  Mu opioid receptor mRNA in nucleus accumbens is elevated following dopamine receptor activation.

Authors:  A V Azaryan; B J Clock; B M Cox
Journal:  Neurochem Res       Date:  1996-11       Impact factor: 3.996

Review 6.  Basal ganglia pathology in schizophrenia: dopamine connections and anomalies.

Authors:  Emma Perez-Costas; Miguel Melendez-Ferro; Rosalinda C Roberts
Journal:  J Neurochem       Date:  2010-01-20       Impact factor: 5.372

7.  Brain region binding of the D2/3 agonist [11C]-(+)-PHNO and the D2/3 antagonist [11C]raclopride in healthy humans.

Authors:  Ariel Graff-Guerrero; Matthaeus Willeit; Nathalie Ginovart; David Mamo; Romina Mizrahi; Pablo Rusjan; Irina Vitcu; Philip Seeman; Alan A Wilson; Shitij Kapur
Journal:  Hum Brain Mapp       Date:  2008-04       Impact factor: 5.038

8.  Assortative human pair-bonding for partner ancestry and allelic variation of the dopamine receptor D4 (DRD4) gene.

Authors:  Dan T A Eisenberg; Coren L Apicella; Benjamin C Campbell; Anna Dreber; Justin R Garcia; J Koji Lum
Journal:  Soc Cogn Affect Neurosci       Date:  2009-08-27       Impact factor: 3.436

Review 9.  Dopamine and glutamate dysfunctions in schizophrenia: role of the dopamine D3 receptor.

Authors:  L Leriche; J Diaz; P Sokoloff
Journal:  Neurotox Res       Date:  2004       Impact factor: 3.911

10.  Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain.

Authors:  Jianjun Sun; Jinbin Xu; Nigel J Cairns; Joel S Perlmutter; Robert H Mach
Journal:  PLoS One       Date:  2012-11-21       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.