Inhibition of the renin-aldosterone response to furosemide by indomethacin.

In 12 human volunteers, indomethacin was shown to inhibit renal prostaglandin produciton as reflected by RIA of urinary PGE2. The increases in plasma renin activity and plasma and urinary aldosterone following acute furosemide challenge were markedly blunted in the presence of indomethacin. In light of recent development indicating an intimate relationship between prostaglandins and renin release, these results provide further evidence for a pivotal role of renal prostaglandins in modulating the responsiveness of the renin-angiotensin-aldosterone axis in Mam.