Literature DB >> 8740524

Prostaglandin-metabolizing enzymes during pregnancy: characterization of NAD(+)-dependent prostaglandin dehydrogenase, carbonyl reductase, and cytochrome P450-dependent prostaglandin omega-hydroxylase.

R T Okita1, J R Okita.   

Abstract

Prostaglandins E2 and F2 alpha regulate a number of physiological functions in reproductive tissues, and concentrations of these bioactive modulators increase during pregnancy. Corresponding to the increase in circulating levels of prostaglandins during pregnancy is an increase in enzymes that metabolize these agents. Three prostaglandin-metabolizing enzymes induced during pregnancy are NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH), NADPH-dependent carbonyl reductase, and cytochrome P450-dependent prostaglandin omega- or 20-hydroxylase. This review discusses the biochemical properties, regulation, and possible functions of these three enzymes.

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Year:  1996        PMID： 8740524     DOI： 10.3109/10409239609106581

Source DB:  PubMed          Journal:  Crit Rev Biochem Mol Biol        ISSN： 1040-9238            Impact factor:   8.250


  9 in total

1.  Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice.

Authors:  Yasushi Hirota; Takiko Daikoku; Susanne Tranguch; Huirong Xie; Heather B Bradshaw; Sudhansu K Dey
Journal:  J Clin Invest       Date:  2010-03       Impact factor: 14.808

2.  Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

Authors:  Jeffrey D Roizen; Minoru Asada; Min Tong; Hsin-Hsiung Tai; Louis J Muglia
Journal:  Mol Endocrinol       Date:  2007-09-13

3.  "Trophoblast islands of the chorionic connective tissue" (TICCT): a novel placental histologic feature.

Authors:  J-S Hong; R Romero; J P Kusanovic; J-S Kim; J Lee; M Jin; H El Azzamy; D-C Lee; V Topping; S Ahn; S Jacques; F Qureshi; T Chaiworapongsa; S S Hassan; S J Korzeniewski; N G Than; C J Kim
Journal:  Placenta       Date:  2013-03-01       Impact factor: 3.481

4.  Increased Expression of 15-Hydroxyprostaglandin Dehydrogenase in Spinal Astrocytes During Disease Progression in a Model of Amyotrophic Lateral Sclerosis.

Authors:  Hiroko Miyagishi; Yasuhiro Kosuge; Ayumi Takano; Manami Endo; Hiroshi Nango; Somay Yamagata-Murayama; Dai Hirose; Rui Kano; Yoko Tanaka; Kumiko Ishige; Yoshihisa Ito
Journal:  Cell Mol Neurobiol       Date:  2016-05-02       Impact factor: 5.046

5.  A randomized crossover study comparing tafluprost 0.0015% with travoprost 0.004% in patients with normal-tension glaucoma [corrected].

Authors:  Takanori Mizoguchi; Mineo Ozaki; Kazuhiko Unoki; Yoshinori Dake; Takahiko Eto; Miki Arai
Journal:  Clin Ophthalmol       Date:  2012-09-25

6.  Development of Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Indomethacin Disposition in Pregnancy.

Authors:  Saeed Alqahtani; Amal Kaddoumi
Journal:  PLoS One       Date:  2015-10-02       Impact factor: 3.240

Review 7.  Regulation of intraluteal production of prostaglandins.

Authors:  Milo C Wiltbank; Joseph S Ottobre
Journal:  Reprod Biol Endocrinol       Date:  2003-11-10       Impact factor: 5.211

Review 8.  The genomics of preterm birth: from animal models to human studies.

Authors:  Katherine Y Bezold; Minna K Karjalainen; Mikko Hallman; Kari Teramo; Louis J Muglia
Journal:  Genome Med       Date:  2013-04-29       Impact factor: 11.117

9.  Down-regulation of HPGD by miR-146b-3p promotes cervical cancer cell proliferation, migration and anchorage-independent growth through activation of STAT3 and AKT pathways.

Authors:  Shuihong Yao; Jingyun Xu; Kaixuan Zhao; Pengxia Song; Qin Yan; Weifei Fan; Wan Li; Chun Lu
Journal:  Cell Death Dis       Date:  2018-10-17       Impact factor: 8.469
  9 in total

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