L W Westerhuis1, W J Venekamp. 1. Department of Clinical Chemistry, Ziekenhuis De Wever & Gregorius, Heerien The Netherlands.
Abstract
OBJECTIVES: Conflicting results for lipoprotein-a (Lp(a)) levels in diabetic patients exist in the literature. Normal, increased, and decreased values are described, and a relation to glycometabolic control is not unequivocally established. DESIGN AND METHODS: In our study Lp(a) was measured in a large group of diabetiee (80 patients with IDDM and 90 patients with NIDDM) in relation to glycometabolic control and the presence of microalbuminuria, retino and/or neuropathy. Long-term and short-term glycometabolic control were assessed by HbA1 and fructosamine assays, respectively. RESULTS: Statistically significant differences between Lp(a) levels in IDDM and NIDDM-and a control group of 110 healthy nondiabetics could not be established. It appeared that the level of Lp(a) in IDDM and NIDDM is independent of short-term and long-term glycometabolic control or the occurrence of microalbuminuria, neuro or retinopathy. However, poor glycometabolic control affected the number of Lp(a) levels elevated above a threshold of 0.25 g/L in IDDM. CONCLUSION: These results suggest that the level of Lp(a) in serum is not influenced by diabetes mellitus, glycemic control, or the occurrence of microalbuminuria, neuro or retinopathy.
OBJECTIVES: Conflicting results for lipoprotein-a (Lp(a)) levels in diabeticpatients exist in the literature. Normal, increased, and decreased values are described, and a relation to glycometabolic control is not unequivocally established. DESIGN AND METHODS: In our study Lp(a) was measured in a large group of diabetiee (80 patients with IDDM and 90 patients with NIDDM) in relation to glycometabolic control and the presence of microalbuminuria, retino and/or neuropathy. Long-term and short-term glycometabolic control were assessed by HbA1 and fructosamine assays, respectively. RESULTS: Statistically significant differences between Lp(a) levels in IDDM and NIDDM-and a control group of 110 healthy nondiabetics could not be established. It appeared that the level of Lp(a) in IDDM and NIDDM is independent of short-term and long-term glycometabolic control or the occurrence of microalbuminuria, neuro or retinopathy. However, poor glycometabolic control affected the number of Lp(a) levels elevated above a threshold of 0.25 g/L in IDDM. CONCLUSION: These results suggest that the level of Lp(a) in serum is not influenced by diabetes mellitus, glycemic control, or the occurrence of microalbuminuria, neuro or retinopathy.
Authors: Sunny S Singh; Mardin Rashid; Aloysius G Lieverse; Florian Kronenberg; Claudia Lamina; Monique T Mulder; Yolanda B de Rijke; Eric J G Sijbrands; Mandy van Hoek Journal: Diabetologia Date: 2020-03-09 Impact factor: 10.122