J A Oosterhuis1. 1. Afdeling Oogheelkunde, Academisch Ziekenhuis, Leiden, The Netherlands.
Abstract
PURPOSE: To study the familial occurrence of central serous retinopathy (CSR). METHODS: We pooled data from eight eye clinics in Western Europe. RESULTS: We collected 11 families that each had two to four members with CSR. In 10 families siblings and in one family a mother and son were affected. Sixty percent of the patients were male and 40% female. CSR was found in 55 (92%) of 60 eyes, 44 (80%) showing a chronic course. In 25 patients (83%) both eyes were affected. Most recent visual acuity was 0.5 or less in 17 (39%) and 0.2 or less in 8 (18%) of the eyes with chronic CSR. CONCLUSION: Our findings of familial occurrence and a chronic disorder that is progressive, diffuse, and bilateral suggest an inborn disposition to develop a clinically manifest disintegration of the retinal pigment epithelium in adulthood.
PURPOSE: To study the familial occurrence of central serous retinopathy (CSR). METHODS: We pooled data from eight eye clinics in Western Europe. RESULTS: We collected 11 families that each had two to four members with CSR. In 10 families siblings and in one family a mother and son were affected. Sixty percent of the patients were male and 40% female. CSR was found in 55 (92%) of 60 eyes, 44 (80%) showing a chronic course. In 25 patients (83%) both eyes were affected. Most recent visual acuity was 0.5 or less in 17 (39%) and 0.2 or less in 8 (18%) of the eyes with chronic CSR. CONCLUSION: Our findings of familial occurrence and a chronic disorder that is progressive, diffuse, and bilateral suggest an inborn disposition to develop a clinically manifest disintegration of the retinal pigment epithelium in adulthood.
Authors: Rosa L Schellevis; Elon H C van Dijk; Myrte B Breukink; Jan E E Keunen; Gijs W E Santen; Carel B Hoyng; Eiko K de Jong; Camiel J F Boon; Anneke I den Hollander Journal: Mol Genet Genomic Med Date: 2019-02-06 Impact factor: 2.183
Authors: Carl Schubert; Anders Pryds; Shemin Zeng; Yajing Xie; K Bailey Freund; Richard F Spaide; John C Merriam; Irene Barbazetto; Jason S Slakter; Stanley Chang; Inger C Munch; Arlene V Drack; Jasmine Hernandez; Suzanne Yzer; Joanna E Merriam; Allan Linneberg; Michael Larsen; Lawrence A Yannuzzi; Robert F Mullins; Rando Allikmets Journal: Hum Mutat Date: 2014-07 Impact factor: 4.700
Authors: Elon H C van Dijk; Roula Tsonaka; Ngaisah Klar-Mohamad; Diana Wouters; Aiko P J de Vries; Eiko K de Jong; Cees van Kooten; Camiel J F Boon Journal: PLoS One Date: 2017-07-03 Impact factor: 3.240
Authors: Jesse J Jung; Daryle Jason G Yu; Kazuyo Ito; Soraya Rofagha; Scott S Lee; Quan V Hoang Journal: Invest Ophthalmol Vis Sci Date: 2020-07-01 Impact factor: 4.799