Literature DB >> 8739346

TSG-6, a glycoprotein associated with arthritis, and its ligand hyaluronan exert opposite effects in a murine model of inflammation.

H G Wisniewski1, D Naime, J C Hua, J Vilcek, B N Cronstein.   

Abstract

TSG-6 is an arthritis-associated hyaluronan binding protein whose production in synovial cells, chondrocytes, fibroblasts and mononuclear cells is stimulated by TNF-alpha and IL-1. The purpose of this study was to gain insights into the role of TSG-6 and its functional interactions with hyaluronan in inflammation. In the murine air pouch model of carrageenan/IL-1-induced inflammation TSG-6 showed a dramatic inhibitory effect on the cellular infiltration of the inflammatory site by neutrophilic PMN, while hyaluronan enhanced cellular infiltration. There was no indication of a neutralizing or cooperative effect when TSG-6 and hyaluronan were injected together. The potent antiinflammatory effect of TSG-6 along with its induction by proinflammatory cytokines suggests that TSG-6 is part of a negative feedback loop in the control of the inflammatory response.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8739346     DOI： 10.1007/bf02346350

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  8 in total

1.  The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

Authors:  B N Cronstein; D Naime; E Ostad
Journal:  J Clin Invest       Date:  1993-12       Impact factor: 14.808

2.  Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis.

Authors:  K Mikecz; F R Brennan; J H Kim; T T Glant
Journal:  Nat Med       Date:  1995-06       Impact factor: 53.440

3.  TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo.

Authors:  H G Wisniewski; J C Hua; D M Poppers; D Naime; J Vilcek; B N Cronstein
Journal:  J Immunol       Date:  1996-02-15       Impact factor: 5.422

4.  TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor.

Authors:  H G Wisniewski; W H Burgess; J D Oppenheim; J Vilcek
Journal:  Biochemistry       Date:  1994-06-14       Impact factor: 3.162

5.  Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1.

Authors:  M Perretti; R J Flower
Journal:  J Immunol       Date:  1993-02-01       Impact factor: 5.422

6.  TSG-6 expression in human articular chondrocytes. Possible implications in joint inflammation and cartilage degradation.

Authors:  R Maier; H G Wisniewski; J Vilcek; M Lotz
Journal:  Arthritis Rheum       Date:  1996-04

7.  TSG-6: a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis.

Authors:  H G Wisniewski; R Maier; M Lotz; S Lee; L Klampfer; T H Lee; J Vilcek
Journal:  J Immunol       Date:  1993-12-01       Impact factor: 5.422

8.  A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44.

Authors:  T H Lee; H G Wisniewski; J Vilcek
Journal:  J Cell Biol       Date:  1992-01       Impact factor: 10.539
  8 in total
  6 in total

1.  sCD44 internalization in human trabecular meshwork cells.

Authors:  Michael J Nolan; Tomoyo Koga; Loyal Walker; Ryan McCarty; Algis Grybauskas; Michael C Giovingo; Kevin Skuran; Paulius V Kuprys; Paul A Knepper
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-01-17       Impact factor: 4.799

2.  TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly.

Authors:  Svetlana A Kuznetsova; David J Mahoney; Gema Martin-Manso; Tariq Ali; Hilke A Nentwich; John M Sipes; Bixi Zeng; Tikva Vogel; Anthony J Day; David D Roberts
Journal:  Matrix Biol       Date:  2007-10-25       Impact factor: 11.583

3.  The N-terminal module of thrombospondin-1 interacts with the link domain of TSG-6 and enhances its covalent association with the heavy chains of inter-alpha-trypsin inhibitor.

Authors:  Svetlana A Kuznetsova; Anthony J Day; David J Mahoney; Marilyn S Rugg; Deane F Mosher; David D Roberts
Journal:  J Biol Chem       Date:  2005-07-08       Impact factor: 5.157

4.  Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model.

Authors:  Jingsheng Tuo; Xiaoguang Cao; Defen Shen; Yujuan Wang; Jun Zhang; Joo Youn Oh; Darwin J Prockop; Chi-Chao Chan
Journal:  J Neuroinflammation       Date:  2012-03-27       Impact factor: 8.322

5.  Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia.

Authors:  Mostafa M Sira; Behairy E Behairy; Azza M Abd-Elaziz; Sameh A Abd Elnaby; Ehab E Eltahan
Journal:  Hepat Res Treat       Date:  2014-09-14

6.  Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6.

Authors:  Virginia Maina; Alessia Cotena; Andrea Doni; Manuela Nebuloni; Fabio Pasqualini; Caroline M Milner; Anthony J Day; Alberto Mantovani; Cecilia Garlanda
Journal:  J Leukoc Biol       Date:  2009-04-23       Impact factor: 4.962
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.