Literature DB >> 8737782

Detection of viral antigen in the endolymphatic sac.

H Kumagami1.   

Abstract

A study was devised to determine whether or not any immune defense mechanism is present when a virus invades the human endolymphatic sac (ES). The ES was removed from 14 fresh autopsy cases having no known pre-mortem diseases in the middle and inner ears. Specimens were then examined for viral antigens including herpes simplex (HSV) type 1 and 2, mumps and cytomegalovirus using immunohistochemical methods. DNA examination by in situ hybridization was also performed for HSV. HSV antigen and DNA were observed in 9 of the 14 cases studied. These findings suggest that the virus invades the ES but is impeded by an immune defense mechanism under normal conditions. Since disease may alter host defenses, further studies are warranted to study the relationship between HSV and patients with Meniere's disease.

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Year:  1996        PMID： 8737782     DOI： 10.1007/bf00171140

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN： 0937-4477            Impact factor:   2.503


  10 in total

Review 1.  Delayed endolymphatic hydrops and its relationship to Meniére's disease.

Authors:  H F Schuknecht; Y Suzuka; C Zimmermann
Journal:  Ann Otol Rhinol Laryngol       Date:  1990-11       Impact factor: 1.547

2.  Herpesviridae in the coronary arteries and aorta of young trauma victims.

Authors:  H M Yamashiroya; L Ghosh; R Yang; A L Robertson
Journal:  Am J Pathol       Date:  1988-01       Impact factor: 4.307

Review 3.  Spiral modiolar vein: its importance in inner ear inflammation.

Authors:  J P Harris; S Fukuda; E M Keithley
Journal:  Acta Otolaryngol       Date:  1990 Nov-Dec       Impact factor: 1.494

4.  Detection of herpes simplex virus DNA from genital lesions by in situ hybridization.

Authors:  A Langenberg; D Smith; C L Brakel; M Pollice; M Remington; C Winter; A Dunne; L Corey
Journal:  J Clin Microbiol       Date:  1988-05       Impact factor: 5.948

5.  The development of endolymphatic hydrops following CMV inoculation of the endolymphatic sac.

Authors:  S Fukuda; E M Keithley; J P Harris
Journal:  Laryngoscope       Date:  1988-04       Impact factor: 3.325

6.  [Qualitative detection of immunoglobulins in the human endolymphatic sac].

Authors:  W Arnold; H J Altermatt; J O Gebbers
Journal:  Laryngol Rhinol Otol (Stuttg)       Date:  1984-09

7.  Delayed endolymphatic hydrops.

Authors:  H F Schuknecht
Journal:  Ann Otol Rhinol Laryngol       Date:  1978 Nov-Dec       Impact factor: 1.547

8.  Herpesvirus hominis: isolation from human trigeminal ganglion.

Authors:  F O Bastian; A S Rabson; C L Yee; T S Tralka
Journal:  Science       Date:  1972-10-20       Impact factor: 47.728

9.  Ménière's disease and antibody reactivity to herpes simplex virus type 1 polypeptides.

Authors:  T Bergström; S Edström; A Tjellström; A Vahlne
Journal:  Am J Otolaryngol       Date:  1992 Sep-Oct       Impact factor: 1.808

10.  Human endolymphatic sac: evidence for a role in inner ear immune defence.

Authors:  H J Altermatt; J O Gebbers; C Müller; W Arnold; J A Laissue
Journal:  ORL J Otorhinolaryngol Relat Spec       Date:  1990       Impact factor: 1.538
  10 in total
  5 in total

1.  No evidence of measles virus in stapes samples from patients with otosclerosis.

Authors:  A B Grayeli; P Palmer; P Tran Ba Huy; J Soudant; O Sterkers; P Lebon; E Ferrary
Journal:  J Clin Microbiol       Date:  2000-07       Impact factor: 5.948

2.  Intratympanic dexamethasone injections for refractory Meniere' s disease.

Authors:  Hongmiao Ren; Tuanfang Yin; Yongde Lu; Weijia Kong; Jihao Ren
Journal:  Int J Clin Exp Med       Date:  2015-04-15

3.  Incidence of virus infection as a cause of Meniere's disease or endolymphatic hydrops assessed by electrocochleography.

Authors:  Ziane Selmani; Timo Marttila; Ilmari Pyykkö
Journal:  Eur Arch Otorhinolaryngol       Date:  2004-07-02       Impact factor: 2.503

4.  Up-Regulated Expression of Interferon-Gamma, Interleukin-6 and Tumor Necrosis Factor-Alpha in the Endolymphatic Sac of Meniere's Disease Suggesting the Local Inflammatory Response Underlies the Mechanism of This Disease.

Authors:  Chao Huang; Qin Wang; Xueying Pan; Wei Li; Wei Liu; Wenqi Jiang; Li Huang; Anquan Peng; Zhiwen Zhang
Journal:  Front Neurol       Date:  2022-02-23       Impact factor: 4.003

Review 5.  Immune system of the inner ear as a novel therapeutic target for sensorineural hearing loss.

Authors:  Takayuki Okano
Journal:  Front Pharmacol       Date:  2014-09-02       Impact factor: 5.810
  5 in total

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