Literature DB >> 8737742

Dithiocarbamates inhibit IL-1-induced cartilage degradation in bovine articular cartilage explants.

J Oleksyszyn1, A J Augustine.   

Abstract

Interleukin-1-stimulated cartilage degradation in bovine articular cartilage explants is effectively inhibited by several different dithiocarbamates with IC50's in the micromolar range.

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Year:  1996        PMID： 8737742     DOI： 10.1007/bf02259605

Source DB:  PubMed          Journal:  Inflamm Res        ISSN： 1023-3830            Impact factor:   4.575


  13 in total

1.  Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines.

Authors:  M L Tiku; J B Liesch; F M Robertson
Journal:  J Immunol       Date:  1990-07-15       Impact factor: 5.422

2.  Effects of proteinase inhibitors on aggrecan catabolism in chondrocyte cultures.

Authors:  C R Flannery; J D Sandy
Journal:  Ann N Y Acad Sci       Date:  1994-09-06       Impact factor: 5.691

3.  Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage.

Authors:  J S Mort; G R Dodge; P J Roughley; J Liu; S J Finch; G DiPasquale; A R Poole
Journal:  Matrix       Date:  1993-03

4.  Effect of oxy radicals on several types of collagen.

Authors:  J C Monboisse; G Poulin; P Braquet; A Randoux; C Ferradini; J P Borel
Journal:  Int J Tissue React       Date:  1984

5.  Articular cartilage cultured with catabolin (pig interleukin 1) synthesizes a decreased number of normal proteoglycan molecules.

Authors:  J A Tyler
Journal:  Biochem J       Date:  1985-05-01       Impact factor: 3.857

6.  Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro.

Authors:  J A Tyler
Journal:  Biochem J       Date:  1985-01-15       Impact factor: 3.857

7.  Antioxidant action of sodium diethyldithiocarbamate: reaction with hydrogen peroxide and superoxide radical.

Authors:  S Mankhetkorn; Z Abedinzadeh; C Houee-Levin
Journal:  Free Radic Biol Med       Date:  1994-12       Impact factor: 7.376

8.  Involvement of reactive oxygen species in cytokine and growth factor induction of c-fos expression in chondrocytes.

Authors:  Y Y Lo; T F Cruz
Journal:  J Biol Chem       Date:  1995-05-19       Impact factor: 5.157

9.  H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

Authors:  M Meyer; R Schreck; P A Baeuerle
Journal:  EMBO J       Date:  1993-05       Impact factor: 11.598

10.  Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

Authors:  R Schreck; B Meier; D N Männel; W Dröge; P A Baeuerle
Journal:  J Exp Med       Date:  1992-05-01       Impact factor: 14.307
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