Literature DB >> 8737680

Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action.

M K Stachowiak1, P A Maher, A Joy, E Mordechai, E K Stachowiak.   

Abstract

Fractionation of human astrocytes revealed the presence of 103, 118, and 145 kDa forms of FGF receptor 1 (FGFR1) in isolated nuclei. Only trace amounts of FGFR1 proteins were detected in the cell membrane or cytoplasmic fractions. Nuclear FGFR1 is found in the nucleoplasm and nuclear matrix but not in chromatin. Immuno-confocal microscopy further demonstrates the intranuclear presence of FGFR1 and its colocalization with FGF-2. Nuclear FGFR1 binds to FGF-2 and has tyrosine kinase activity. Translocation of functional growth factor receptors into the cell nucleus offers a novel mechanism for growth factor action.

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Year:  1996        PMID： 8737680     DOI： 10.1016/0169-328x(96)00010-1

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  29 in total

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Review 4.  Biological function of nuclear receptor tyrosine kinase action.

Authors:  Sungmin Song; Kenneth M Rosen; Gabriel Corfas
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-07-01       Impact factor: 10.005

Review 5.  Nuclear trafficking of the epidermal growth factor receptor family membrane proteins.

Authors:  Y-N Wang; H Yamaguchi; J-M Hsu; M-C Hung
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6.  Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells.

Authors:  M K Stachowiak; P A Maher; A Joy; E Mordechai; E K Stachowiak
Journal:  Mol Biol Cell       Date:  1996-08       Impact factor: 4.138

Review 7.  Nuclear Fibroblast Growth Factor Receptor Signaling in Skeletal Development and Disease.

Authors:  Creighton T Tuzon; Diana Rigueur; Amy E Merrill
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8.  Common developmental genome deprogramming in schizophrenia - Role of Integrative Nuclear FGFR1 Signaling (INFS).

Authors:  S T Narla; Y-W Lee; C A Benson; P Sarder; K J Brennand; E K Stachowiak; M K Stachowiak
Journal:  Schizophr Res       Date:  2017-01-13       Impact factor: 4.939

9.  Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop.

Authors:  Mattias K Andersson; Melker Göransson; Anita Olofsson; Carola Andersson; Pierre Aman
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10.  Fibroblast growth factor-2 regulates the stability of nuclear bodies.

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Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-17       Impact factor: 11.205
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