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Literature DB >> 8736547

WW domains.

Abstract

WW domains are recently described protein-protein interaction modules; they bind to proline-rich sequences that usually also contain a tyrosine. These domains have been detected in several unrelated proteins, often alongside other domains. Recent studies suggest that WW domains in specific proteins may play a role in diseases such as hypertension or muscular dystrophy.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1996 PMID： 8736547 DOI： 10.1016/s0969-2126(96)00054-8

Source DB: PubMed Journal: Structure ISSN： 0969-2126 Impact factor: 5.006

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Cited

28 in total

1. Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

Authors: H Abriel; J Loffing; J F Rebhun; J H Pratt; L Schild; J D Horisberger; D Rotin; O Staub
Journal: J Clin Invest Date: 1999-03 Impact factor: 14.808

2. Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity.

Authors: Ali Khoshnan; Jan Ko; Paul H Patterson
Journal: Proc Natl Acad Sci U S A Date: 2002-01-15 Impact factor: 11.205

3. Peptides containing cyclin/Cdk-nuclear localization signal motifs derived from viral initiator proteins bind to DNA when unphosphorylated.

Authors: Ronald J Kim; Stephanie Moine; Danielle K Reese; Peter A Bullock
Journal: J Virol Date: 2002-12 Impact factor: 5.103

4. A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.

Authors: R Yagi; L F Chen; K Shigesada; Y Murakami; Y Ito
Journal: EMBO J Date: 1999-05-04 Impact factor: 11.598

5. A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.

Authors: R N Harty; M E Brown; G Wang; J Huibregtse; F P Hayes
Journal: Proc Natl Acad Sci U S A Date: 2000-12-05 Impact factor: 11.205

WW domains.

1. Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

2. Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity.

3. Peptides containing cyclin/Cdk-nuclear localization signal motifs derived from viral initiator proteins bind to DNA when unphosphorylated.

4. A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.

5. A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.

6. Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.

Review 7. ITCH as a potential therapeutic target in human cancers.

8. SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors.

9. Supramolecular properties of the proline-rich gamma-Zein N-terminal domain.

10. Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity.