Literature DB >> 8735986

Peptides and growth factors in non-small cell lung cancer.

T W Moody1.   

Abstract

Numerous growth factors and receptors that alter proliferation have been identified in lung cancer. In non-small cell lung cancer (NSCLC) cell lines, high levels of vasoactive intestinal peptide (VIP) mRNA have been detected by Northern analysis, and immunoreactive VIP is present. VIP elevates intracellular cAMP and stimulates the clonal growth of NSCLC cells. Also, transforming growth factor alpha (TGF-alpha) mRNA is present in NSCLC cells and TGF-alpha is present in conditioned media exposed to NSCLC cells. TGF-alpha binds with high affinity to epidermal growth factor (EGF) receptors present on NSCLC cells. EGF stimulates tyrosine kinase activity and growth in NSCLC cells. Synthetic peptide antagonists and monoclonal antibodies have been identified that disrupt autocrine growth pathways and inhibit NSCLC growth. These data suggest that VIP and TGF-alpha are important autocrine growth factors for NSCLC.

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Year:  1996        PMID： 8735986     DOI： 10.1016/0196-9781(95)02148-5

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  7 in total

1.  Antagonistic actions of analogs related to growth hormone-releasing hormone (GHRH) on receptors for GHRH and vasoactive intestinal peptide on rat pituitary and pineal cells in vitro.

Authors:  Z Rekasi; J L Varga; A V Schally; G Halmos; K Groot; T Czompoly
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

2.  The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues.

Authors:  Alexandre Havt; Andrew V Schally; Gabor Halmos; Jozsef L Varga; Gabor L Toller; Judit E Horvath; Karoly Szepeshazi; Frank Köster; Kevin Kovitz; Kate Groot; Marta Zarandi; Celia A Kanashiro
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-18       Impact factor: 11.205

3.  Increased susceptibility to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in transgenic mice overexpressing c-myc and epidermal growth factor in alveolar type II cells.

Authors:  A Ehrhardt; T Bartels; R Klocke; D Paul; R Halter
Journal:  J Cancer Res Clin Oncol       Date:  2003-02-19       Impact factor: 4.553

4.  Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.

Authors:  Z Rekasi; T Czompoly; A V Schally; G Halmos
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

5.  Relevance of Somatostatin Receptors and Other Peptide Receptors in Pathology.

Authors:  Jean Claude Reubi
Journal:  Endocr Pathol       Date:  1997       Impact factor: 3.943

Review 6.  Targeting VIP and PACAP receptor signalling: new therapeutic strategies in multiple sclerosis.

Authors:  Yossan-Var Tan; James A Waschek
Journal:  ASN Neuro       Date:  2011-10-06       Impact factor: 4.146

7.  Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c-myc and epidermal growth factor in alveolar type II pneumocytes.

Authors:  A Ehrhardt; T Bartels; A Geick; R Klocke; D Paul; R Halter
Journal:  Br J Cancer       Date:  2001-03-23       Impact factor: 7.640
  7 in total

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