Literature DB >> 8734357

Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease.

J M Reimund1, C Wittersheim, S Dumont, C D Muller, R Baumann, P Poindron, B Duclos.   

Abstract

Chronic inflammation in inflammatory bowel disease (IBD; Crohn's disease and ulcerative colitis) may be attributed partly to increased secretion of inflammatory cytokines. The aim of this study was to investigate simultaneously the spontaneous release patterns of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1 beta), and interleukin-6 (IL-6) by organ cultures of inflamed mucosa from IBD patients. Organ cultures of involved IBD mucosa spontaneously produced increased amounts of TNF-alpha, IL-1 beta, and IL-6 compared to normal mucosa. The patterns of cytokine release between Crohn's disease and ulcerative colitis organ cultures were not significantly different. Increased inflammatory cytokine production by lamina propria mononuclear cells (LPMCs) and mucosa treated with EDTA suggests that these cytokines originate mainly from LPMCs. These results confirm the role of inflammatory cytokines in IBD and shed a new light on the role of TNF-alpha in IBD.

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Year:  1996        PMID： 8734357     DOI： 10.1007/bf01540912

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  27 in total

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Journal:  Gut       Date:  1989-06       Impact factor: 23.059

2.  Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine.

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Journal:  Clin Exp Immunol       Date:  1990-08       Impact factor: 4.330

3.  Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease.

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Journal:  Gastroenterology       Date:  1995-01       Impact factor: 22.682

4.  Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease.

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Journal:  Gastroenterology       Date:  1994-06       Impact factor: 22.682

5.  Colonic mucosal interleukin-6 in inflammatory bowel disease.

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Journal:  Digestion       Date:  1991       Impact factor: 3.216

6.  Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent.

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Journal:  Dig Dis Sci       Date:  1995-05       Impact factor: 3.199

7.  Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells.

Authors:  F Powrie; M W Leach; S Mauze; S Menon; L B Caddle; R L Coffman
Journal:  Immunity       Date:  1994-10       Impact factor: 31.745

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Authors:  J Brynskov; N Tvede; C B Andersen; M Vilien
Journal:  Gut       Date:  1992-01       Impact factor: 23.059

9.  Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.

Authors:  V Casini-Raggi; L Kam; Y J Chong; C Fiocchi; T T Pizarro; F Cominelli
Journal:  J Immunol       Date:  1995-03-01       Impact factor: 5.422

10.  Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

Authors:  F Powrie; R Correa-Oliveira; S Mauze; R L Coffman
Journal:  J Exp Med       Date:  1994-02-01       Impact factor: 14.307
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  62 in total

1.  Enhanced production of IL-8 in chronic but not in early ileal lesions of Crohn's disease (CD).

Authors:  E Brandt; J F Colombel; N Ectors; L Gambiez; D Emilie; K Geboes; M Capron; P Desreumaux
Journal:  Clin Exp Immunol       Date:  2000-11       Impact factor: 4.330

Review 2.  Clinically useful monoclonal antibodies in treatment.

Authors:  E Drewe; R J Powell
Journal:  J Clin Pathol       Date:  2002-02       Impact factor: 3.411

3.  Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease.

Authors:  Nobuki Ichikawa; Kenichiro Yamashita; Tohru Funakoshi; Shin Ichihara; Moto Fukai; Masaomi Ogura; Nozomi Kobayashi; Masaaki Zaitsu; Tadashi Yoshida; Susumu Shibasaki; Yasuyuki Koshizuka; Yusuke Tsunetoshi; Masanori Sato; Takahiro Einama; Michitaka Ozaki; Kazuo Umezawa; Tomomi Suzuki; Satoru Todo
Journal:  Inflamm Res       Date:  2015-12-18       Impact factor: 4.575

Review 4.  Economic implications of biological therapies for Crohn's disease: review of infliximab.

Authors:  Keith Bodger
Journal:  Pharmacoeconomics       Date:  2005       Impact factor: 4.981

5.  Amelioration of psoriasis by anti-TNF-alpha RNAi in the xenograft transplantation model.

Authors:  Maria Jakobsen; Karin Stenderup; Cecilia Rosada; Brian Moldt; Søren Kamp; Tomas N Dam; Thomas G Jensen; Jacob Giehm Mikkelsen
Journal:  Mol Ther       Date:  2009-06-30       Impact factor: 11.454

6.  Immuno-epithelial interactions: cytokine modulation of normal rabbit colonocyte function.

Authors:  A Vidrich; P A Anton; F Shanahan
Journal:  In Vitro Cell Dev Biol Anim       Date:  1998 Nov-Dec       Impact factor: 2.416

7.  Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice.

Authors:  Luigia De Fazio; Elena Cavazza; Enzo Spisni; Antonio Strillacci; Manuela Centanni; Marco Candela; Chiara Praticò; Massimo Campieri; Chiara Ricci; Maria Chiara Valerii
Journal:  World J Gastroenterol       Date:  2014-02-28       Impact factor: 5.742

8.  Allelic variation at the interleukin 1beta gene is associated with decreased bone mass in patients with inflammatory bowel diseases.

Authors:  A Nemetz; M Tóth; M A García-González; T Zágoni; J Fehér; A S Peña; Z Tulassay
Journal:  Gut       Date:  2001-11       Impact factor: 23.059

Review 9.  Role of cytokines in inflammatory bowel disease.

Authors:  Fausto Sanchez-Munoz; Aaron Dominguez-Lopez; Jesus-K Yamamoto-Furusho
Journal:  World J Gastroenterol       Date:  2008-07-21       Impact factor: 5.742

10.  Multivariate modeling identifies neutrophil- and Th17-related factors as differential serum biomarkers of chronic murine colitis.

Authors:  Megan E McBee; Yu Zeng; Nicola Parry; Cathryn R Nagler; Steven R Tannenbaum; David B Schauer
Journal:  PLoS One       Date:  2010-10-19       Impact factor: 3.240
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