Literature DB >> 8734356

Characterization of interleukin-15 (IL-15) and the IL-15 receptor complex.

M K Kennedy1, L S Park.   

Abstract

IL-15 interacts with a heterotrimeric receptor that consists of the beta and gamma subunits of the IL-2 receptor (IL-2R) as well as a specific, high-affinity IL-15-binding subunit, which is designated IL-15R alpha. Since both the beta and the gamma subunits of the IL-2R are required for signaling by either IL-2 or IL-15, it is not surprising that these cytokines share many activities in vitro. However, the differential expression of these cytokines and the alpha chains of their receptors within various tissues and cell types suggests that IL-2 and IL-15 may perform at least partially distinct physiological functions. The production of IL-15 by macrophages, and possibly other cell types, in response to environmental stimuli and infectious agents suggests that IL-15 may play a role in protective immune responses, allograft rejection, and the pathogenesis of autoimmune diseases.

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Year:  1996        PMID： 8734356     DOI： 10.1007/bf01540911

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  54 in total

1.  Cytokine gene expression during the generation of human lymphokine-activated killer cells: early induction of interleukin 1 beta by interleukin 2.

Authors:  E J Kovacs; S K Beckner; D L Longo; L Varesio; H A Young
Journal:  Cancer Res       Date:  1989-02-15       Impact factor: 12.701

2.  A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

Authors:  J D Burton; R N Bamford; C Peters; A J Grant; G Kurys; C K Goldman; J Brennan; E Roessler; T A Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

3.  The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.

Authors:  R N Bamford; A J Grant; J D Burton; C Peters; G Kurys; C K Goldman; J Brennan; E Roessler; T A Waldmann
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-24       Impact factor: 11.205

4.  Immune responses in interleukin-2-deficient mice.

Authors:  T M Kündig; H Schorle; M F Bachmann; H Hengartner; R M Zinkernagel; I Horak
Journal:  Science       Date:  1993-11-12       Impact factor: 47.728

5.  Evidence for the continuous recruitment and activation of T cells into the joints of patients with rheumatoid arthritis.

Authors:  F Iannone; V M Corrigall; G H Kingsley; G S Panayi
Journal:  Eur J Immunol       Date:  1994-11       Impact factor: 5.532

6.  Interleukin-15 and the growth of tumor derived activated T-cells.

Authors:  W M Lewko; T L Smith; D J Bowman; R W Good; R K Oldham
Journal:  Cancer Biother       Date:  1995

7.  A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods.

Authors:  S J Perkins; P I Haris; R B Sim; D Chapman
Journal:  Biochemistry       Date:  1988-05-31       Impact factor: 3.162

8.  Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15.

Authors:  L Flamand; I Stefanescu; J Menezes
Journal:  J Clin Invest       Date:  1996-03-15       Impact factor: 14.808

9.  Interleukin (IL)-15 promotes the growth of murine epidermal gamma delta T cells by a mechanism involving the beta- and gamma c-chains of the IL-2 receptor.

Authors:  D Edelbaum; M Mohamadzadeh; P R Bergstresser; K Sugamura; A Takashima
Journal:  J Invest Dermatol       Date:  1995-12       Impact factor: 8.551

10.  Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis.

Authors:  G S Firestein; W D Xu; K Townsend; D Broide; J Alvaro-Gracia; A Glasebrook; N J Zvaifler
Journal:  J Exp Med       Date:  1988-11-01       Impact factor: 14.307
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  23 in total

1.  Identification of the earliest natural killer cell-committed progenitor in murine bone marrow.

Authors:  John W Fathman; Deepta Bhattacharya; Matthew A Inlay; Jun Seita; Holger Karsunky; Irving L Weissman
Journal:  Blood       Date:  2011-09-19       Impact factor: 22.113

2.  Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques.

Authors:  Maren Q DeGottardi; Afam A Okoye; Mukta Vaidya; Aarthi Talla; Audrie L Konfe; Matthew D Reyes; Joseph A Clock; Derick M Duell; Alfred W Legasse; Amit Sabnis; Byung S Park; Michael K Axthelm; Jacob D Estes; Keith A Reiman; Rafick-Pierre Sekaly; Louis J Picker
Journal:  J Immunol       Date:  2016-07-18       Impact factor: 5.422

3.  Cytokine profile in the liver of primary biliary cirrhosis.

Authors:  T Nagano; K Yamamoto; S Matsumoto; R Okamoto; M Tagashira; N Ibuki; S Matsumura; K Yabushita; N Okano; T Tsuji
Journal:  J Clin Immunol       Date:  1999-11       Impact factor: 8.317

Review 4.  Extrinsic and intrinsic regulation of early natural killer cell development.

Authors:  Markus D Boos; Kevin Ramirez; Barbara L Kee
Journal:  Immunol Res       Date:  2008       Impact factor: 2.829

Review 5.  Functions of IL-15 in anti-viral immunity: multiplicity and variety.

Authors:  Katherine C Verbist; Kimberly D Klonowski
Journal:  Cytokine       Date:  2012-06-15       Impact factor: 3.861

6.  Attenuation of Allergen-, IL-13-, and TGF-α-induced Lung Fibrosis after the Treatment of rIL-15 in Mice.

Authors:  Sathisha Upparahalli Venkateshaiah; Rituraj Niranjan; Murli Manohar; Alok K Verma; Hemanth K Kandikattu; Joseph A Lasky; Anil Mishra
Journal:  Am J Respir Cell Mol Biol       Date:  2019-07       Impact factor: 6.914

Review 7.  Development and functions of natural killer cells.

Authors:  Akira Shibuya
Journal:  Int J Hematol       Date:  2003-07       Impact factor: 2.490

8.  IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses.

Authors:  Yvonne M Mueller; Duc H Do; Susan R Altork; Carol M Artlett; Edward J Gracely; Christos D Katsetos; Agustin Legido; Francois Villinger; John D Altman; Charles R Brown; Mark G Lewis; Peter D Katsikis
Journal:  J Immunol       Date:  2008-01-01       Impact factor: 5.422

9.  Expression of interleukin-15 and its receptor on the surface of stimulated human umbilical vein endothelial cells.

Authors:  Xiuping Liu; Yumei Zuo; Weina Zhang; Deguang Yang; Changyun Xiong; Xiaozhou Zhang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2009-10-11

10.  The liver plays a major role in clearance and destruction of blood trypomastigotes in Trypanosoma cruzi chronically infected mice.

Authors:  Luiz Roberto Sardinha; Tainá Mosca; Rosa Maria Elias; Rogério Silva do Nascimento; Lígia A Gonçalves; Daniella Zanetti Bucci; Cláudio Romero Farias Marinho; Carlos Penha-Gonçalves; Maria Regina D'Império Lima; José Maria Alvarez
Journal:  PLoS Negl Trop Dis       Date:  2010-01-05
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