Literature DB >> 873327

Effect of lysolecithin on gastric mucosal structure and potential difference.

R Orchard, K Reynolds, B Fox, R Andrews, R A Parkins, A G Johnson.   

Abstract

The effect of lysolecithin (100 mg%) on the guinea-pig gastric mucosa was studied by instilling a solution for 30 minutes, preceded and followed by 100 MN HCl into 10 total gastric pouches. Ten control animals had HCl throughout. Lysolecithin produced a significant change in transmucosal potential difference, macroscopic erosions, and mucosal damage on histology and electron scanning microscopy. None of these changes was seen in the control animals. This is further evidence that the reflux of lysolecithin from the duodenum is an important factor in causing active gastritis and gastric erosions.

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Year:  1977        PMID： 873327      PMCID： PMC1411517          DOI： 10.1136/gut.18.6.457

Source DB:  PubMed          Journal:  Gut        ISSN： 0017-5749            Impact factor:   23.059


  3 in total

1.  Effect of lysolecithin, digitonin, and phospholipase A upon the dog's gastric mucosal barrier.

Authors:  H W Davenport
Journal:  Gastroenterology       Date:  1970-10       Impact factor: 22.682

2.  Increased reflux of bile into the stomach in patients with gastric ulcer.

Authors:  J Rhodes; D E Barnardo; S F Phillips; R A Rovelstad; A F Hofmann
Journal:  Gastroenterology       Date:  1969-09       Impact factor: 22.682

3.  Lysolecithin: a factor in the pathogenesis of gastric ulceration?

Authors:  A G Johnson; S J McDermott
Journal:  Gut       Date:  1974-09       Impact factor: 23.059
  3 in total
  6 in total

1.  Gastric mucosal damage induced by combination of ethanol and lysophosphatidylcholine.

Authors:  D H Neiderhiser; J Maksem
Journal:  Dig Dis Sci       Date:  1987-06       Impact factor: 3.199

2.  Gastric mucosal toxicity of duodenal juice constituents in the rat. Acute studies using ex vivo rat gastric chamber model.

Authors:  D Armstrong; E R Rytina; G M Murphy; R H Dowling
Journal:  Dig Dis Sci       Date:  1994-02       Impact factor: 3.199

Review 3.  Alkaline reflux gastritis: a critical reappraisal.

Authors:  W P Ritchie
Journal:  Gut       Date:  1984-09       Impact factor: 23.059

4.  Lysophosphatidylcholine-induced gastric injury and ulceration in the guinea pig.

Authors:  J Maksem; N Jacobson; D H Neiderhiser
Journal:  Am J Pathol       Date:  1984-05       Impact factor: 4.307

5.  Bile acid and lysolecithin concentrations in the stomach in patients with duodenal ulcer before operation and after treatment by highly selective vagotomy, partial gastrectomy, or truncal vagotomy and drainage.

Authors:  P Dewar; R King; D Johnston
Journal:  Gut       Date:  1982-07       Impact factor: 23.059

6.  Relationship of Campylobacter pylori and duodenogastric reflux.

Authors:  S Niemelä; T Karttunen; J Heikkilä; O Mäentausta; J Lehtola
Journal:  Dig Dis Sci       Date:  1989-07       Impact factor: 3.199
  6 in total

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