Literature DB >> 8731932

Immunoregulatory effects of indomethacin on rats with trauma.

Y C Pan1, S X Zhang, X Z Ding, H Li.   

Abstract

In this article, we investigated changes of immune functions and immunoregulatory effects of indomethacin on rats with trauma. The results show that spontaneous suppressor T cell activity of spleen significantly increased and Interleukin I production and DNA synthesis capacity of splenocytes markedly decreased in rats with trauma. Indomethacin could markedly improve immune function, decreased spontaneous suppressor T cell activity and prompted Interleukin 2 production and DNA synthesis capacity of splenocytes.

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Year:  1995        PMID： 8731932     DOI： 10.1007/BF02887953

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  10 in total

1.  Postburn immunosuppression in an animal model. III. Maintenance of normal splenic helper and suppressor lymphocyte subpopulations by immunomodulating drugs.

Authors:  R L Zapata-Sirvent; J F Hansbrough
Journal:  Surgery       Date:  1985-06       Impact factor: 3.982

2.  Prevention of alterations in postoperative lymphocyte subpopulations by cimetidine and ibuprofen.

Authors:  J F Hansbrough; R L Zapata-Sirvent; E M Bender
Journal:  Am J Surg       Date:  1986-02       Impact factor: 2.565

Review 3.  Production and assay of the interleukins.

Authors:  A J Gearing; A P Johnstone; R Thorpe
Journal:  J Immunol Methods       Date:  1985-10-24       Impact factor: 2.303

Review 4.  Prostaglandins and host defense in cancer.

Authors:  J S Goodwin
Journal:  Med Clin North Am       Date:  1981-07       Impact factor: 5.456

5.  Participation of prostaglandin E in immunosuppression following thermal injury.

Authors:  J L Ninnemann; A E Stockland
Journal:  J Trauma       Date:  1984-03

6.  Suppression of interleukin 2 production in an animal model of thermal injury is related to prostaglandin synthesis.

Authors:  J J Wood; J T Grbic; M L Rodrick; A Jordan; J A Mannick
Journal:  Arch Surg       Date:  1987-02

7.  Prostaglandin E2 (PGE2)-dependent suppression of interleukin alpha (IL-2) production in patients with major trauma.

Authors:  E Faist; A Mewes; C C Baker; T Strasser; S S Alkan; P Rieber; G Heberer
Journal:  J Trauma       Date:  1987-08

8.  Immunomodulatory therapy with thymopentin and indomethacin. Successful restoration of interleukin-2 synthesis in patients undergoing major surgery.

Authors:  E Faist; A Markewitz; D Fuchs; S Lang; S Zarius; F W Schildberg; H Wachter; B Reichart
Journal:  Ann Surg       Date:  1991-09       Impact factor: 12.969

9.  Nonsteroidal anti-inflammatory drugs correct the bactericidal defect of polymorphonuclear leukocytes in a guinea pig model of thermal injury.

Authors:  A B Bjornson; R W Knippenberg; H S Bjornson
Journal:  J Infect Dis       Date:  1988-05       Impact factor: 5.226

10.  Changes in T cell subsets and T suppressor cell function and their relationship in human schistosomiasis japonica.

Authors:  Z J Li; D D Luo; J Z Dai; L L Zheng; X H Wang; Y X Yang
Journal:  J Tongji Med Univ       Date:  1991
  10 in total

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