Literature DB >> 8731455

Analysis of chromosome 18 DNA markers in multiplex pedigrees with manic depression.

H Coon1, M Hoff, J Holik, D Hadley, N Fang, F Reimherr, P Wender, W Byerley.   

Abstract

Six pedigrees segregating manic-depressive illness (MDI) were analyzed for linkage to 21 highly polymorphic microsatellite DNA markers on chromosome 18. These markers span almost the entire length of the chromosome, and gaps between markers are less than 20 cM. In particular, we analyzed several markers localizing to the pericentromeric region of chromosome 18 which generated lod scores suggestive of linkage in an independent study. Lod score analysis was performed and results were examined by family. One region produced positive lod scores, though at 18q23 and not in the pericentromeric region. We additionally used two nonparametric methods because the true mode of transmission of MDI is unknown; results were again somewhat suggestive for markers in the region of 18q23 but not in the pericentromeric region.

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Year:  1996        PMID： 8731455     DOI： 10.1016/0006-3223(95)00292-8

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN： 0006-3223            Impact factor:   13.382


  6 in total

1.  Linkage of bipolar affective disorder to chromosome 18 markers in a new pedigree series.

Authors:  F J McMahon; P J Hopkins; J Xu; M G McInnis; S Shaw; L Cardon; S G Simpson; D F MacKinnon; O C Stine; R Sherrington; D A Meyers; J R DePaulo
Journal:  Am J Hum Genet       Date:  1997-12       Impact factor: 11.025

2.  A follow-up report of a genome search for affective disorder predisposition loci in the Old Order Amish.

Authors:  M C LaBuda; M Maldonado; D Marshall; K Otten; D S Gerhard
Journal:  Am J Hum Genet       Date:  1996-12       Impact factor: 11.025

3.  A susceptibility locus for bipolar affective disorder on chromosome 4q35.

Authors:  L J Adams; P B Mitchell; S L Fielder; A Rosso; J A Donald; P R Schofield
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

4.  No evidence for significant linkage between bipolar affective disorder and chromosome 18 pericentromeric markers in a large series of multiplex extended pedigrees.

Authors:  J A Knowles; P A Rao; T Cox-Matise; J E Loth; G M de Jesus; L Levine; K Das; G K Penchaszadeh; J R Alexander; B Lerer; J Endicott; J Ott; T C Gilliam; M Baron
Journal:  Am J Hum Genet       Date:  1998-04       Impact factor: 11.025

5.  Support for a chromosome 18p locus conferring susceptibility to functional psychoses in families with schizophrenia, by association and linkage analysis.

Authors:  S G Schwab; J Hallmayer; B Lerer; M Albus; M Borrmann; S Hönig; M Strauss; R Segman; D Lichtermann; M Knapp; M Trixler; W Maier; D B Wildenauer
Journal:  Am J Hum Genet       Date:  1998-10       Impact factor: 11.025

6.  Molecular linkage studies of bipolar disorder.

Authors:  W H Berrettini
Journal:  Dialogues Clin Neurosci       Date:  1999-06       Impact factor: 5.986
  6 in total

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