Literature DB >> 8730817

Decreased density of I2-imidazoline receptors in the postmortem brain of heroin addicts.

M Sastre1, P Ventayol, J A García-Sevilla.   

Abstract

The aim of this study was to quantitate imidazoline receptors in postmortem brains of heroin addicts who died of an opiate overdose. The density of I2-imidazoline receptors ([3H]idazoxan binding in the presence of adrenaline) and the immunoreactivity of the related 29/30 kDa imidazoline receptor protein were decreased (39% and 28%, respectively) in the frontal cortex. The density of brain I2-imidazoline receptors was also decreased in heroin-dependent rats (27%). This novel finding indicates that opiate addiction induces down-regulation of I2-imidazoline receptors in astrocytes, and presumably down-regulation of the functions associated with these receptors.

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Year:  1996        PMID： 8730817     DOI： 10.1097/00001756-199601310-00032

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  9 in total

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Authors:  P V Escribá; R Alemany; M Sastre; G Olmos; A Ozaita; J A García-Sevilla
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  9 in total

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