Literature DB >> 8730800

Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease.

J H Su1, T Satou, A J Anderson, C W Cotman.   

Abstract

Cell death and neurofibrillary tangle formation are prominent features of Alzheimer's disease (AD). It has been suggested that DNA damage may reflect neuronal vulnerability. In this context, the Ced homologue Bcl-2 is able to repress a number of cell death programs. Recently we found both numerous nuclei exhibiting DNA damage within neurons in the AD brain and increases in Bcl-2 immunoreactivity. In this study, we examined the relationship between Bcl-2 expression and nuclear DNA damage or tangle formation. Nuclei exhibiting DNA damage were associated with an up-regulation of Bcl-2 expression, whereas tangle-bearing neurons were associated with a down-regulation of Bcl-2 expression.

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Year:  1996        PMID： 8730800     DOI： 10.1097/00001756-199601310-00015

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  10 in total

1.  Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

Authors:  C Stadelmann; T L Deckwerth; A Srinivasan; C Bancher; W Brück; K Jellinger; H Lassmann
Journal:  Am J Pathol       Date:  1999-11       Impact factor: 4.307

2.  Differential nigral expression of bcl-2 protein family in the pure and common forms of Dementia with Lewy bodies: relevance for dopaminergic neuronal vulnerability.

Authors:  M Saldaña; E Aguilar; M Bonastre; C Marin
Journal:  J Neural Transm (Vienna)       Date:  2007-07-04       Impact factor: 3.575

3.  Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease.

Authors:  T T Rohn; E Head; J H Su; A J Anderson; B A Bahr; C W Cotman; D H Cribbs
Journal:  Am J Pathol       Date:  2001-01       Impact factor: 4.307

Review 4.  The biochemistry of Alzheimer's disease.

Authors:  G J Stege; G J Bosman
Journal:  Drugs Aging       Date:  1999-06       Impact factor: 3.923

Review 5.  Transcriptional regulation of the BCL-X gene by NF-kappaB is an element of hypoxic responses in the rat brain.

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Journal:  Neurochem Res       Date:  2001-06       Impact factor: 3.996

6.  Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease.

Authors:  Rukhsana Sultana; William A Banks; D Allan Butterfield
Journal:  J Neurosci Res       Date:  2010-02-15       Impact factor: 4.164

7.  Loss of phospholipid asymmetry and elevated brain apoptotic protein levels in subjects with amnestic mild cognitive impairment and Alzheimer disease.

Authors:  Miranda L Bader Lange; Giovanna Cenini; Marta Piroddi; Hafiz Mohmmad Abdul; Rukhsana Sultana; Francesco Galli; Maurizio Memo; D Allan Butterfield
Journal:  Neurobiol Dis       Date:  2007-11-12       Impact factor: 5.996

Review 8.  The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease.

Authors:  Manon Callens; Nina Kraskovskaya; Kristina Derevtsova; Wim Annaert; Geert Bultynck; Ilya Bezprozvanny; Tim Vervliet
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2021-03-09       Impact factor: 4.739

Review 9.  P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?

Authors:  Aleksandra Szybińska; Wiesława Leśniak
Journal:  Aging Dis       Date:  2017-07-21       Impact factor: 6.745

Review 10.  Molecular crosstalk between cancer and neurodegenerative diseases.

Authors:  Jiyeon Seo; Mikyoung Park
Journal:  Cell Mol Life Sci       Date:  2019-12-28       Impact factor: 9.261
  10 in total

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