Literature DB >> 8730728

Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres.

F L Puisieux1, M M Adamantidis, B M Dumotier, B A Dupuis.   

Abstract

Cisapride, a gastrointestinal prokinetic agent, has been associated with cases of Torsades de Pointes but its effects on the cardiac action potential have not been described. We investigated its electrophysiological effects on rabbit isolated Purkinje fibres. The results demonstrated that cisapride (0.01-10 microM) lengthened concentration-dependently the action potential duration without modifying other parameters and induced early after depolarizations and subsequent triggered activity. This typical class III antiarrhythmic effect, that showed "reverse" rate-dependence and was reduced by increasing external K concentration, can account for clinical arrhythmogenesis.

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Year:  1996        PMID： 8730728      PMCID： PMC1909459          DOI： 10.1111/j.1476-5381.1996.tb15295.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

Review 1.  Electrophysiologic substrate of torsade de pointes: dispersion of repolarization or early afterdepolarizations?

Authors:  B Surawicz
Journal:  J Am Coll Cardiol       Date:  1989-07       Impact factor: 24.094

Review 2.  Cisapride. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use as a prokinetic agent in gastrointestinal motility disorders.

Authors:  R W McCallum; C Prakash; D M Campoli-Richards; K L Goa
Journal:  Drugs       Date:  1988-12       Impact factor: 9.546

3.  Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence.

Authors:  L M Hondeghem; D J Snyders
Journal:  Circulation       Date:  1990-02       Impact factor: 29.690

4.  Electrophysiological and arrhythmogenic effects of the histamine type 1-receptor antagonist astemizole on rabbit Purkinje fibers: clinical relevance.

Authors:  M M Adamantidis; D L Lacroix; J F Caron; B A Dupuis
Journal:  J Cardiovasc Pharmacol       Date:  1995-08       Impact factor: 3.105

Review 5.  Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes.

Authors:  C Antzelevitch; S Sicouri
Journal:  J Am Coll Cardiol       Date:  1994-01       Impact factor: 24.094

6.  Long QT syndrome during high-dose cisapride.

Authors:  S Bran; W A Murray; I B Hirsch; J P Palmer
Journal:  Arch Intern Med       Date:  1995-04-10
  6 in total
  14 in total

Review 1.  Preclinical in vitro cardiac electrophysiology: a method of predicting arrhythmogenic potential of antihistamines in humans?

Authors:  I Cavero; M Mestre; J M Guillon; E Heuillet; A G Roach
Journal:  Drug Saf       Date:  1999       Impact factor: 5.606

2.  Calcium-voltage coupling in the genesis of early and delayed afterdepolarizations in cardiac myocytes.

Authors:  Zhen Song; Christopher Y Ko; Michael Nivala; James N Weiss; Zhilin Qu
Journal:  Biophys J       Date:  2015-04-21       Impact factor: 4.033

3.  Effects of cisapride on QTc interval in neonates.

Authors:  S Bernardini; D S Semama; F Huet; C Sgro; J B Gouyon
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  1997-11       Impact factor: 5.747

Review 4.  Irritable bowel syndrome: new agents targeting serotonin receptor subtypes.

Authors:  F De Ponti; M Tonini
Journal:  Drugs       Date:  2001       Impact factor: 9.546

5.  Application of the bradford hill criteria to assess the causality of cisapride-induced arrhythmia: a model for assessing causal association in pharmacovigilance.

Authors:  Michael Perrio; Simon Voss; Saad A W Shakir
Journal:  Drug Saf       Date:  2007       Impact factor: 5.606

Review 6.  Cardiovascular safety of prokinetic agents: A focus on drug-induced arrhythmias.

Authors:  J R Giudicessi; M J Ackerman; M Camilleri
Journal:  Neurogastroenterol Motil       Date:  2018-02-14       Impact factor: 3.598

Review 7.  Drug interactions with cisapride: clinical implications.

Authors:  E L Michalets; C R Williams
Journal:  Clin Pharmacokinet       Date:  2000-07       Impact factor: 6.447

8.  Cisapride improves enteral tolerance in pediatric short-bowel syndrome with dysmotility.

Authors:  Bram P Raphael; Samuel Nurko; Hongyu Jiang; Kristen Hart; Daniel S Kamin; Tom Jaksic; Christopher Duggan
Journal:  J Pediatr Gastroenterol Nutr       Date:  2011-05       Impact factor: 2.839

9.  Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice.

Authors:  Z Desta; K T Kivistö; J J Lilja; J T Backman; N Soukhova; P J Neuvonen; D A Flockhart
Journal:  Br J Clin Pharmacol       Date:  2001-10       Impact factor: 4.335

10.  Effects of cisapride on QTc interval in term neonates.

Authors:  D S Semama; S Bernardini; S Louf; B Laurent-Atthalin; J B Gouyon
Journal:  Arch Dis Child Fetal Neonatal Ed       Date:  2001-01       Impact factor: 5.747
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