Literature DB >> 873069

The effect of insulin on vascular reactivity to norepinephrine.

W D Alexander, R J Oake.   

Abstract

The effect of insulin on the vasoconstrictor response to norepinephrine of the resistance bed of the isolated perfused rat tail has been studied. Insulin produced a significant attenuation of this response in concentrations of both 120 mU./ml. and 150 micronU./ml. It is suggested that this effect may be relevant to the hypotensive action of insulin observed in diabetics.

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Year:  1977        PMID： 873069     DOI： 10.2337/diab.26.7.611

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  15 in total

1.  Effects of insulin on renal haemodynamics and the proximal and distal tubular sodium handling in healthy subjects.

Authors:  P Stenvinkel; J Bolinder; A Alvestrand
Journal:  Diabetologia       Date:  1992-11       Impact factor: 10.122

2.  Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.

Authors:  E A Anderson; R P Hoffman; T W Balon; C A Sinkey; A L Mark
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

3.  Hyperinsulinaemia is not linked with blood pressure elevation in patients with insulinoma.

Authors:  P T Sawicki; L Heinemann; A Starke; M Berger
Journal:  Diabetologia       Date:  1992-07       Impact factor: 10.122

Review 4.  Insulin resistance and hypertension--implications for treatment.

Authors:  P A Rutherford; T H Thomas; R Wilkinson
Journal:  Postgrad Med J       Date:  1991-10       Impact factor: 2.401

5.  Mechanisms mediating insulin-induced hypotension in rats. A role for nitric oxide and autonomic mediators.

Authors:  J C Dunbar; D S O'Leary; G Wang; J Wright-Richey
Journal:  Acta Diabetol       Date:  1996-12       Impact factor: 4.280

6.  Hypertension, insulin, and proinsulin in participants with impaired glucose tolerance.

Authors: 
Journal:  Hypertension       Date:  2002-11       Impact factor: 10.190

7.  Studies on the influence of insulin on cyclic adenosine monophosphate in human vascular smooth muscle cells: dependence on cyclic guanosine monophosphate and modulation of catecholamine effects.

Authors:  M Trovati; P Massucco; L Mattiello; F Cavalot; E M Mularoni; A W Hahn; G Anfossi
Journal:  Diabetologia       Date:  1996-10       Impact factor: 10.122

8.  Cardiovascular effects of insulin: plasma volume changes in diabetics.

Authors:  J D Mackay; H Hayakawa; P J Watkins
Journal:  Diabetologia       Date:  1978-12       Impact factor: 10.122

9.  Interactions between insulin and norepinephrine on blood pressure and insulin sensitivity. Studies in lean and obese men.

Authors:  A D Baron; G Brechtel; A Johnson; N Fineberg; D P Henry; H O Steinberg
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808

10.  Insulin attenuates agonist-mediated calcium mobilization in cultured rat vascular smooth muscle cells.

Authors:  F Saito; M T Hori; M Fittingoff; T Hino; M L Tuck
Journal:  J Clin Invest       Date:  1993-09       Impact factor: 14.808
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