Literature DB >> 872874

Fenfluramine long-term administration and brain serotonin.

J Duhault, M Boulanger.   

Abstract

Long-term administration of fenfluarmine induced a decrease of brain 5-HT to the same extent as did an acute dose. 48 h after drug withdrawal, the brain serotonin level returned to the control value. The present study provides evidence to suggest that a degenerative lesion of 5-HT neurons is not involved in fenfluramine activity.

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Year:  1977        PMID: 872874     DOI: 10.1016/0014-2999(77)90133-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN: 0014-2999            Impact factor:   4.432


  1 in total

1.  Discriminative stimulus properties of fenfluramine: evidence for serotonergic involvement.

Authors:  J F McElroy; R S Feldman
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

  1 in total

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