Transgenic mice: models for the study of cataractogenesis. A minireview.

Genetic manipulation followed by (over)expression of the transgene product in lens tissue results in: (I) inhibition of denucleation of lens fibers; (II) interference with lens cell differentiation; (III) cataract formation. The events reviewed are preceded by membrane damage, perturbed assembly of the IF cytoskeleton and distortion of the cytoskeleton-membrane complex.