Literature DB >> 8727207

Identification of an epitope for T-cells correlated with antibody response to hepatitis B surface antigen in vaccinated humans.

W P Min1, N Kamikawaji, M Mineta, T Tana, S Kashiwagi, T Sasazuki.   

Abstract

Two antigenic T-cell epitopes of HBsAg, designated HBs 16-31 and HBs 81-99, were identified using synthetic peptides and HBsAg-specific T-cell lines. HBs 16-31 was recognized by five HBsAg-specific T-cell lines from vaccinees with both high and low antibody titers, whereas HBs 81-99 was recognized by two T-cell lines derived from vaccinees with high antibody titers. The antibody titer against HBsAg was correlated significantly with the proliferation of vaccinee's PBLs in response to HBs 81-99 (r = 0.47) but not to HBs 16-31, suggesting that HBs 81-99 plays a critical role in anti-HBs antibody production in humans vaccinated with HBsAg.

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Year:  1996        PMID： 8727207     DOI： 10.1016/0198-8859(96)00009-2

Source DB:  PubMed          Journal:  Hum Immunol        ISSN： 0198-8859            Impact factor:   2.850


  6 in total

1.  Characterization of the T cell recognition of hepatitis B surface antigen (HBsAg) by good and poor responders to hepatitis B vaccines.

Authors:  I Desombere; Y Gijbels; A Verwulgen; G Leroux-Roels
Journal:  Clin Exp Immunol       Date:  2000-12       Impact factor: 4.330

2.  Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope prediction.

Authors:  Julia Schwaiger; Judith H Aberle; Karin Stiasny; Bernhard Knapp; Wolfgang Schreiner; Ingrid Fae; Gottfried Fischer; Ondrej Scheinost; Vaclav Chmelik; Franz X Heinz
Journal:  J Virol       Date:  2014-04-30       Impact factor: 5.103

3.  Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen.

Authors:  P C Tai; D Banik; G I Lin; S Pai; K Pai; M H Lin; G Yuoh; S Che; S H Hsu; T C Chen; T T Kuo; C S Lee; C S Yang; C Shih
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

Review 4.  Therapeutic vaccination for treatment of chronic hepatitis B.

Authors:  Tamsin Cargill; Eleanor Barnes
Journal:  Clin Exp Immunol       Date:  2021-06-08       Impact factor: 5.732

5.  Genogeography and Immune Epitope Characteristics of Hepatitis B Virus Genotype C Reveals Two Distinct Types: Asian and Papua-Pacific.

Authors:  Meta Dewi Thedja; David Handojo Muljono; Susan Irawati Ie; Erick Sidarta; Jan Verhoef; Sangkot Marzuki
Journal:  PLoS One       Date:  2015-07-10       Impact factor: 3.240

Review 6.  T cell epitope: friend or foe? Immunogenicity of biologics in context.

Authors:  Constanze A Weber; Preema J Mehta; Matt Ardito; Lenny Moise; Bill Martin; Anne S De Groot
Journal:  Adv Drug Deliv Rev       Date:  2009-07-18       Impact factor: 15.470
  6 in total

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