Literature DB >> 8726035

Reporter gene technology to assess activity of antimycobacterial agents in macrophages.

T M Arain1, A E Resconi, D C Singh, C K Stover.   

Abstract

Reporter strains of Mycobacterium tuberculosis and Mycobacterium bovis BCG endogenously expressing firefly luciferase were used in bioluminescence assays to evaluate the activities of isoniazid and rifampin against mycobacteria sequestered in human macrophages. This methodology allowed the efficacy of antibiotics against intracellular mycobacteria to be assessed without the labor-intensive procedures and protracted incubation requirements associated with conventional CFU determinations.

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Year:  1996        PMID： 8726035      PMCID： PMC163365          DOI： 10.1128/AAC.40.6.1542

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  The combined effect of rifampin and pyrazinamide within the human macrophage.

Authors:  J A Sbarbaro; M D Iseman; A J Crowle
Journal:  Am Rev Respir Dis       Date:  1992-12

2.  The action of new antituberculous drugs on intracellular tubercle bacilli.

Authors:  V Clini; C Grassi
Journal:  Antibiot Chemother       Date:  1970

3.  MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages.

Authors:  N Mor; L Heifets
Journal:  Antimicrob Agents Chemother       Date:  1993-01       Impact factor: 5.191

4.  A rapid method for screening antimicrobial agents for activities against a strain of Mycobacterium tuberculosis expressing firefly luciferase.

Authors:  R C Cooksey; J T Crawford; W R Jacobs; T M Shinnick
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

5.  Antibiotic uptake by alveolar macrophages.

Authors:  J D Johnson; W L Hand; J B Francis; N King-Thompson; R W Corwin
Journal:  J Lab Clin Med       Date:  1980-03

6.  Vancomycin-gentamicin synergism revisited: effect of gentamicin susceptibility of methicillin-resistant Staphylococcus aureus.

Authors:  L Mulazimoglu; S D Drenning; R R Muder
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

7.  Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages.

Authors:  W R Jacobs; R G Barletta; R Udani; J Chan; G Kalkut; G Sosne; T Kieser; G J Sarkis; G F Hatfull; B R Bloom
Journal:  Science       Date:  1993-05-07       Impact factor: 47.728

8.  Efficacies of liposome-encapsulated clarithromycin and ofloxacin against Mycobacterium avium-M. intracellulare complex in human macrophages.

Authors:  C O Onyeji; C H Nightingale; D P Nicolau; R Quintiliani
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

9.  Antibiotic entry into human polymorphonuclear leukocytes.

Authors:  R C Prokesch; W L Hand
Journal:  Antimicrob Agents Chemother       Date:  1982-03       Impact factor: 5.191

10.  Activity in vitro of rifabutin, FCE 22807, rifapentine, and rifampin against Mycobacterium microti and M. tuberculosis and their penetration into mouse peritoneal macrophages.

Authors:  J Dhillon; D A Mitchison
Journal:  Am Rev Respir Dis       Date:  1992-01
  10 in total
  20 in total

1.  The stringent response of Mycobacterium tuberculosis is required for long-term survival.

Authors:  T P Primm; S J Andersen; V Mizrahi; D Avarbock; H Rubin; C E Barry
Journal:  J Bacteriol       Date:  2000-09       Impact factor: 3.490

Review 2.  Use of aminoglycosides in treatment of infections due to intracellular bacteria.

Authors:  M Maurin; D Raoult
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

3.  Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter.

Authors:  Chartchai Changsen; Scott G Franzblau; Prasit Palittapongarnpim
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

4.  Alternative luciferase for monitoring bacterial cells under adverse conditions.

Authors:  Siouxsie Wiles; Kathryn Ferguson; Martha Stefanidou; Douglas B Young; Brian D Robertson
Journal:  Appl Environ Microbiol       Date:  2005-07       Impact factor: 4.792

5.  How novel methods can help discover more information about foodborne pathogens.

Authors:  M W Griffiths
Journal:  Can J Infect Dis       Date:  2000-05

6.  Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains.

Authors:  D Deidda; G Lampis; R Fioravanti; M Biava; G C Porretta; S Zanetti; R Pompei
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

7.  Development of a firefly luciferase-based assay for determining antimicrobial susceptibility of Mycobacterium avium subsp. paratuberculosis.

Authors:  S L Williams; N B Harris; R G Barletta
Journal:  J Clin Microbiol       Date:  1999-02       Impact factor: 5.948

8.  Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery.

Authors:  T M Arain; A E Resconi; M J Hickey; C K Stover
Journal:  Antimicrob Agents Chemother       Date:  1996-06       Impact factor: 5.191

9.  The tuberculosis epidemic. Scientific challenges and opportunities.

Authors:  A M Ginsberg
Journal:  Public Health Rep       Date:  1998 Mar-Apr       Impact factor: 2.792

10.  Simple fibroblast-based assay for screening of new antimicrobial drugs against Mycobacterium tuberculosis.

Authors:  Takemasa Takii; Yoshifumi Yamamoto; Taku Chiba; Chiyoji Abe; John T Belisle; Patrick J Brennan; Kikuo Onozaki
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191
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