Literature DB >> 8726032

Oxygen concentration influences proton pump inhibitor activity against Helicobacter pylori in vitro.

P D Midolo1, J D Turnidge, J R Lambert, J M Bell.   

Abstract

Omeprazole and lansoprazole are proton pump inhibitors that have shown activity against Helicobacter pylori and other Helicobacter species when tested by agar dilution. Lansoprazole was more active against H. pylori than was omeprazole, and the activity was independent of urease production. Disk susceptibility tests and agar dilution MIC determinations were performed to investigate the effects of incubation under different sets of atmospheric conditions on H. pylori inhibition. Oxygen concentration was found to influence proton pump inhibitor activity in vitro, with higher concentrations leading to greater susceptibility. The method of testing is important in determining the anti-Helicobacter activity of proton pump inhibitors.

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Year:  1996        PMID： 8726032      PMCID： PMC163362          DOI： 10.1128/AAC.40.6.1531

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori.

Authors:  T Iwahi; H Satoh; M Nakao; T Iwasaki; T Yamazaki; K Kubo; T Tamura; A Imada
Journal:  Antimicrob Agents Chemother       Date:  1991-03       Impact factor: 5.191

2.  Antibacterial activity of pantoprazole and omeprazole against Helicobacter pylori.

Authors:  S Suerbaum; H Leying; K Klemm; W Opferkuch
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1991-02       Impact factor: 3.267

3.  The mechanism of action of the gastric acid secretion inhibitor omeprazole.

Authors:  P Lindberg; P Nordberg; T Alminger; A Brändström; B Wallmark
Journal:  J Med Chem       Date:  1986-08       Impact factor: 7.446

4.  Lack of in vitro activity of omeprazole against Campylobacter pylori.

Authors:  A M Ghelani; S Hale; H Coleman; H Radziwonik; C Robertson; M Atkinson
Journal:  J Clin Pathol       Date:  1990-02       Impact factor: 3.411

5.  Identification and characterization of an ATPase system of Helicobacter pylori and the effect of proton pump inhibitors.

Authors:  F Mauch; G Bode; P Malfertheiner
Journal:  Am J Gastroenterol       Date:  1993-10       Impact factor: 10.864

6.  The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism.

Authors:  C C McGowan; T L Cover; M J Blaser
Journal:  Gastroenterology       Date:  1994-09       Impact factor: 22.682

7.  Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase.

Authors:  E Fellenius; T Berglindh; G Sachs; L Olbe; B Elander; S E Sjöstrand; B Wallmark
Journal:  Nature       Date:  1981-03-12       Impact factor: 49.962

8.  Reduced amoxicillin uptake into human gastric mucosa when gastric juice pH is high.

Authors:  G Cardaci; J R Lambert; R G King; N Onishi; P Midolo
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

9.  Effect of omeprazole on concentrations of clarithromycin in plasma and gastric tissue at steady state.

Authors:  L E Gustavson; J F Kaiser; A L Edmonds; C S Locke; M L DeBartolo; D W Schneck
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

10.  Inhibitory action of lansoprazole and its analogs against Helicobacter pylori: inhibition of growth is not related to inhibition of urease.

Authors:  K Nagata; E Takagi; M Tsuda; T Nakazawa; H Satoh; M Nakao; H Okamura; T Tamura
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191
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  4 in total

1.  Basis for the selective antibacterial activity in vitro of proton pump inhibitors against Helicobacter spp.

Authors:  J E Sjøstrøm; T Kühler; H Larsson
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

2.  Inhibitory activities of lansoprazole against respiration in Helicobacter pylori.

Authors:  K Nagata; N Sone; T Tamura
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

Review 3.  Clinical relevance of genetic polymorphisms in the human CYP2C subfamily.

Authors:  J A Goldstein
Journal:  Br J Clin Pharmacol       Date:  2001-10       Impact factor: 4.335

4.  Antileishmanial activity of the antiulcer agent omeprazole.

Authors:  Suping Jiang; Juliana Meadows; Steven A Anderson; Antony J Mukkada
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191
  4 in total

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