Literature DB >> 8725938

Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates.

H Singh1.   

Abstract

Specification of B- and T-lymphoid cell fates appears to involve the expression of a shared set of genes encoding recombination proteins and of genes encoding lineage-specific components of antigen receptors. Recent studies using gene targeting have identified transcription factors that are required for the proper specification of lymphoid cell fates. On the basis of these data, a regulatory gene hierarchy which orchestrates the development of lymphoid progenitors from hematopoietic stem cells can be proposed.

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Year:  1996        PMID： 8725938     DOI： 10.1016/s0952-7915(96)80053-7

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  12 in total

1.  Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4.

Authors:  Yong-Hao Hou; Edward F Srour; Heather Ramsey; Richard Dahl; Hal E Broxmeyer; Robert Hromas
Journal:  Blood       Date:  2005-01-13       Impact factor: 22.113

Review 2.  Progression of regulatory gene expression states in fetal and adult pro-T-cell development.

Authors:  Elizabeth-Sharon David-Fung; Mary A Yui; Marissa Morales; Hua Wang; Tom Taghon; Rochelle A Diamond; Ellen V Rothenberg
Journal:  Immunol Rev       Date:  2006-02       Impact factor: 12.988

3.  Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin.

Authors:  K Hahm; B S Cobb; A S McCarty; K E Brown; C A Klug; R Lee; K Akashi; I L Weissman; A G Fisher; S T Smale
Journal:  Genes Dev       Date:  1998-03-15       Impact factor: 11.361

4.  Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes.

Authors:  C A Klug; S J Morrison; M Masek; K Hahm; S T Smale; I L Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-20       Impact factor: 11.205

5.  Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter.

Authors:  M Sigvardsson
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

6.  Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

Authors:  S R McKercher; B E Torbett; K L Anderson; G W Henkel; D J Vestal; H Baribault; M Klemsz; A J Feeney; G E Wu; C J Paige; R A Maki
Journal:  EMBO J       Date:  1996-10-15       Impact factor: 11.598

7.  Eicosapentaenoic acid demethylates a single CpG that mediates expression of tumor suppressor CCAAT/enhancer-binding protein delta in U937 leukemia cells.

Authors:  Veronica Ceccarelli; Serena Racanicchi; Maria Paola Martelli; Giuseppe Nocentini; Katia Fettucciari; Carlo Riccardi; Pierfrancesco Marconi; Paolo Di Nardo; Francesco Grignani; Luciano Binaglia; Alba Vecchini
Journal:  J Biol Chem       Date:  2011-06-09       Impact factor: 5.157

8.  PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.

Authors:  R P DeKoter; J C Walsh; H Singh
Journal:  EMBO J       Date:  1998-08-03       Impact factor: 11.598

9.  A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates.

Authors:  Chauncey J Spooner; Jason X Cheng; Elisabet Pujadas; Peter Laslo; Harinder Singh
Journal:  Immunity       Date:  2009-10-08       Impact factor: 31.745

Review 10.  The BLyS family: toward a molecular understanding of B cell homeostasis.

Authors:  John F Treml; Yi Hao; Jason E Stadanlick; Michael P Cancro
Journal:  Cell Biochem Biophys       Date:  2008-11-26       Impact factor: 2.194
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