Literature DB >> 8724453

Somatodendritic 5-HT1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT.

S M Remy1, R Schreiber, M Dalmus, J De Vry.   

Abstract

In the rat shock-induced ultrasonic vocalization test, the anxiolytic effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) obtained after systemic (IP) and intracerebral injection into the dorsal raphe nucleus (DRN) were selectively abolished by pretreatment with the 5-HT1A receptor antagonist WAY-100635 [N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclo-hexane-carboxamide trihydrochloride]. This blockade was demonstrated both after systemic and DRN application of WAY-100635. Therefore, it is concluded that the anxiolytic effects of 8-OH-DPAT are mediated by activation of somatodendritic 5-HT1A receptors.

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Year:  1996        PMID： 8724453     DOI： 10.1007/BF02247397

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  6 in total

1.  Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs.

Authors:  J De Vry; U Benz; R Schreiber; J Traber
Journal:  Eur J Pharmacol       Date:  1993-11-16       Impact factor: 4.432

2.  Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: neurobiological correlates.

Authors:  H Sommermeyer; R Schreiber; J M Greuel; J De Vry; T Glaser
Journal:  Eur J Pharmacol       Date:  1993-08-10       Impact factor: 4.432

3.  Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat?

Authors:  T Jolas; R Schreiber; A M Laporte; M Chastanet; J De Vry; T Glaser; J Adrien; M Hamon
Journal:  J Pharmacol Exp Ther       Date:  1995-02       Impact factor: 4.030

4.  Conditioned ultrasonic distress vocalizations in adult male rats as a behavioural paradigm for screening anti-panic drugs.

Authors:  H E Molewijk; A M van der Poel; J Mos; J A van der Heyden; B Olivier
Journal:  Psychopharmacology (Berl)       Date:  1995-01       Impact factor: 4.530

Review 5.  5-HT1A receptor agonists: recent developments and controversial issues.

Authors:  J De Vry
Journal:  Psychopharmacology (Berl)       Date:  1995-09       Impact factor: 4.530

6.  Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat.

Authors:  R Schreiber; J De Vry
Journal:  Eur J Pharmacol       Date:  1993-11-16       Impact factor: 4.432
  6 in total
  9 in total

1.  The use of sudden darkness in mice: a behavioural and pharmacological approach.

Authors:  Bettina Bert; Luciano F Felicio; Heidrun Fink; Antonia G Nasello
Journal:  Psychopharmacology (Berl)       Date:  2004-12-24       Impact factor: 4.530

Review 2.  Regulation of dorsal raphe nucleus function by serotonin autoreceptors: a behavioral perspective.

Authors:  Ross A McDevitt; John F Neumaier
Journal:  J Chem Neuroanat       Date:  2011-05-08       Impact factor: 3.052

3.  Agonist-induced internalization of serotonin-1a receptors in the dorsal raphe nucleus (autoreceptors) but not hippocampus (heteroreceptors).

Authors:  M Riad; K C Watkins; E Doucet; M Hamon; L Descarries
Journal:  J Neurosci       Date:  2001-11-01       Impact factor: 6.167

4.  Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.

Authors:  L K Heisler; H M Chu; T J Brennan; J A Danao; P Bajwa; L H Parsons; L H Tecott
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205

5.  Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats.

Authors:  Adam J Prus; Todd M Hillhouse; Amber L LaCrosse
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2013-11-23       Impact factor: 5.067

6.  Differential effects of exposure to low-light or high-light open-field on anxiety-related behaviors: relationship to c-Fos expression in serotonergic and non-serotonergic neurons in the dorsal raphe nucleus.

Authors:  J Adriaan Bouwknecht; Francesca Spiga; Daniel R Staub; Matthew W Hale; Anantha Shekhar; Christopher A Lowry
Journal:  Brain Res Bull       Date:  2007-01-16       Impact factor: 4.077

7.  Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain.

Authors:  Javier A Bravo; Timothy G Dinan; John F Cryan
Journal:  Front Mol Neurosci       Date:  2014-04-10       Impact factor: 5.639

8.  Activation of somatodendritic 5-HT1A autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test.

Authors:  Yulong Zhao; Elisabeth Y Bijlsma; Freija Ter Heegde; Monika P Verdouw; J Garssen; Adrian Newman-Tancredi; Lucianne Groenink
Journal:  Psychopharmacology (Berl)       Date:  2018-12-12       Impact factor: 4.530

Review 9.  Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation.

Authors:  Stefan M Brudzynski
Journal:  Brain Sci       Date:  2021-05-09
  9 in total

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